Elsevier

The Lancet

Volume 343, Issue 8891, 22 January 1994, Pages 208-209
The Lancet

Reduced transfer of tetanus antibodies with placental malaria

https://doi.org/10.1016/S0140-6736(94)90991-1Get rights and content

Abstract

Placental malaria may limit antibody transfer to the fetus. We compared concentrations of tetanus antibody in paired maternal-cord sera from 224 women living in a malarious area of Papus New Guinea. With heavy placental infection (>35 parasites per 200 white cells) the average cold tetanus antibody corresponding to a maternal level of 1 IU/mL was 0·18 (95% Cl 0·12–0·26); corresponding figures after light (<35 parasites per 200 white cells) or no infection were 0·23 (0·14–0·34) and 0·82 (0·57–1·21), respectively. About 10% of babies born to mothers with a placental heavily infected with Plasmodium falciparummay fall to acquire protective levels of tetanus antibody despite adequate maternal antibody.

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