Ultrasound measurement of gastric emptying time in patients with cystic fibrosis and effect of ranitidine on delayed gastric emptying☆,☆☆,★
Section snippets
METHODS
In 29 patients with CF (16 girls; median age, 10.2 years; range, 5 to 17 years), gastric emptying time of a solid-liquid mixed meal was measured by ultrasonography of the stomach. In all patients, the diagnosis of CF had been established through a previous positive sweat test result (sweat chloride determination, >70 mmol/L) and the presence of typical clinical symptoms and signs. Patients entering into the study had not exhibited severe clinical features of intestinal dysmotility, such as
RESULTS
Gastric emptying time was significantly delayed in patients with CF in comparison with control subjects; distention of the antral area (percentage of increase compared with baseline value) was markedly higher in patients with CF both 60 and 90 minutes after feeding, in comparison with control subjects (Table I). Twenty-six patients with CF had a gastric emptying time beyond the range of values measured in the control subjects; these patients were randomly allocated to receive either cisapride
DISCUSSION
This study shows that gastric motor abnormalities such as delayed gastric emptying and exaggerated postfeeding antral distention can be found in a high proportion of patients with CF. Gastric motility was assessed through real-time ultrasonography, a recently introduced and validated tool for studying the gastric motor profile.11, 13, 14 Previous reports on patients with CF had shown a normal gastric emptying time of liquid meals.15, 16 Gastric emptying time is commonly believed to be
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2016, Journal of Cystic FibrosisCitation Excerpt :No study to date has investigated PERT efficacy when given after meals in CF. Gastric emptying has been found to be accelerated [9], normal [10] and delayed [11] in CF when compared to controls. The degree of improvement in pancreatic lipase activity with PERT has been shown to be reduced in children with CF with slower gastric emptying [6].
Gastric emptying and gastro-oesophageal reflux in children with cystic fibrosis
2016, Journal of Cystic FibrosisCitation Excerpt :This could be expected as we defined DGE as t1/2-GE > P90 and RGE as t1/2-GE < P10 according to normal values established in healthy children (submitted). DGE for solids, solid/liquid meal and liquids was reported respectively in 72.7%, 89.7% and 33.3% of children with CF [8,24,25]. DGE for solids and liquids was found respectively between 5.8% and 97.0% and between 0% and 67.0% of adults with CF [7,26–29].
Reduced levels of active GLP-1 in patients with cystic fibrosis with and without diabetes mellitus
2012, Journal of Cystic FibrosisErythromycin improves gastric emptying half-time in adult cystic fibrosis patients with gastroparesis
2009, Journal of Cystic FibrosisCitation Excerpt :Multiple diagnostic modalities using a variety of protocols have provided conflicting results regarding the presence of gastric dysmotility in patients with cystic fibrosis. Studies have described normal [4–6], delayed [2,7–10] or accelerated [11,12] gastric emptying rates. Gastroparesis has been described in cystic fibrosis predominantly in children and patients with advanced lung disease.
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From the Department of Pediatrics, University of Naples “Federico II,” Naples, Italy
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Reprint requests: Salvatore Cucchiara, MD, Department of Pediatrics, Gastrointestinal Motility and Endoscopy Unit, University of Naples “Federico II,” Via S.Pansini 5, 80131 Napoli, Italy.
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0022-3476/96/$5.00 + 0 9/20/71607