Hemodynamic prediction of complications in neonatal respiratory distress syndrome☆,☆☆,★,★★
Section snippets
METHODS
Twenty-nine healthy preterm control infants and 63 infants with RDS were studied prospectively (Table I). Infants with sepsis, aspiration, and congenital anomalies were excluded from the study. Cardiac Doppler ultrasound examinations were performed in infants at the mean ages of 2, 24, 48, and 72 hours; some of the examinations were unsuccessful because of the unstable condition of some infants. The infants were treated by the attending physicians, who were unaware of the results of the APPG
RESULTS
Spontaneous closure of the ductus arteriosus in 17 control subjects and 11 infants with RDS during the first day of life led to their exclusion from the study. In 12 healthy control subjects, the mean APPG increased on the first day of life from 6.3 ± 0.9 (mean ± SEM) to 18.6 ± 1.7 mm Hg (Figure). Ductal APPG either increased or remained low in infants with RDS, and the criterion described above was used for separating these patients into two groups. In 26 infants with RDS, the ductal pressure
DISCUSSION
This study shows that the mean APPG rapidly increases after birth in healthy preterm infants and in infants with uncomplicated neonatal RDS. On the other hand, infants with RDS who have a minimal increase in mean ductal APPG during the first day of life had most of the acute neonatal complications.
Early prophylactic closure of the PDA, especially in surfactant-treated infants, has been advocated as a way of diminishing the need for ventilatory support and avoiding serious acute and late
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Cited by (14)
Exogenous surfactant therapy
2022, Goldsmith's Assisted Ventilation of the Neonate: An Evidence-Based Approach to Newborn Respiratory Care, Seventh EditionPharmacologic Therapies I: Surfactant Therapy
2017, Assisted Ventilation of the Neonate: An Evidence-Based Approach to Newborn Respiratory Care: Sixth EditionPharmacologic Adjuncts II. Exogenous Surfactants
2011, Assisted Ventilation of the NeonatePharmacologic adjuncts ii: Exogenous surfactants exogenous surfactants
2010, Assisted Ventilation of the Neonate: Expert Consult - Online and PrintPharmacologic Adjuncts II: Exogenous Surfactants
2003, Assisted Ventilation of the NeonateDiagnosis of patent ductus arteriosus
2001, Seminars in Neonatology
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From the Department of Pediatrics, University of Turku, Turku, Finland
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Supported by the South-West Finland Fund of Neonatal Research and the Foundation of Turku University.
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Reprint requests: Marko Seppänen, BM, Department of Pediatrics, University of Turku, Kiinamyllynkatu 4-8, 20520 Turku, Finland.
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0022-3476/95/$5.00 + 0 9/23/67179