Early echocardiographic prediction of symptomatic patent ductus arteriosus in preterm infants undergoing mechanical ventilation☆,☆☆,★
Section snippets
METHODS
One hundred sixteen premature infants weighing less than 1500 gm and with respiratory symptoms likely to require ventilation for more than 24 hours underwent echocardiographic studies between 7 and 31 hours of life (mean, 19 hours). Two study enrollment periods were included in the analysis. The first (48 babies) had echocardiograms obtained on a daily basis for the first 7 days; measurements were done early, but occasionally the investigator knew the outcome with respect to a significant PDA.
Population
During the two study periods (February 1992 through March 1993 and June 1993 through July 1994) a total of 145 infants admitted to our neonatal intensive care unit met the entry criteria for the study. Of these, 21 (14%) were not studied because neither of the investigators was available to perform echocardiography; 124 infants (86%) were entered into the study. Of these, eight were excluded from the analysis-three because they were scanned after 48 hours of age, one because of the presence of
DISCUSSION
This study has demonstrated that early prediction of a significant PDA is possible using the measurement of ductal diameter on color flow Doppler mapping. It seems that the rate of early ductal constriction is closely related to the likelihood of later development of significant PDA. Eleven infants had large ducts on the first day that subsequently closed spontaneously (false-positive group). This group was more mature and had a higher average birth weight. Their greater maturity may enable
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2022, Seminars in Fetal and Neonatal MedicineEarly Role of the Atrial-Level Communication in Premature Infants with Patent Ductus Arteriosus
2021, Journal of the American Society of EchocardiographyCitation Excerpt :One marker that is most often used is that of ductal diameter. Although it has been shown that ductal size measurement is weakly correlated with shunt volume, unindexed ductal diameter showed the best correlation,13 and the absolute diameter chosen for this study (≥1.5 mm) is consistent with hsPDA.29,30 It is important to note that the degree of intra- and extracardiac shunting is influenced by other factors, including but not limited to ventricular compliance, pulmonary vascular resistance, and intrathoracic pressure.
Oral ibuprofen promoted cholestatic liver disease in very low birth weight infants with patent ductus arteriosus
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From the Department of Perinatal Medicine, King George Vth Hospital, Royal Prince Alfred Hospitals, Camperdown, Australia
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Reprint requests: Nick Evans, DM, Department of Perinatal Medicine, King George Vth Hospital, Missenden Rd., Camperdown, New South Wales 2050, Australia.
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0022-3476/95/$5.00 + 0 9/23/67469