Clinical and laboratory observation
Protective levels of serum antibodies stimulated in infants by two injections of Haemophilus influenzae type b capsular polysaccharide-tetanus toxoid conjugate*

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Cited by (81)

  • Carrier priming or suppression: Understanding carrier priming enhancement of anti-polysaccharide antibody response to conjugate vaccines

    2014, Vaccine
    Citation Excerpt :

    Booy et al. [41] found that early immunization schedule of DTP resulted in a significantly lower immune response than a later one, which suggest that with an accelerated schedule, maternal antibodies can have an inhibitory effect on the responses to immunization against tetanus and pertussis. However, the inhibitory effects of passively acquired maternal TT antibodies on the antibody response to HibV-TT was demonstrated in a RCT [42], such effects were not seen if infants were primed with TT one month prior to immunization with HibV-TT in other observational studies [25,43,44]. There are several RCTs comparing different immunization schedules for PCV in infants in terms of timing and number of doses.

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The clinical protocol, information sheet and consent form (84-CH-109), and vaccine standardization data (BBIND 1977) for this study were reviewed by the Medical Board of the National Institutes of Health, U.S. Food and Drug Administration, the Ethical Committee of the University of Gothenburg, and the Drug Department of the Swedish Board of Health and Welfare.

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