Effect of mineral supplementation of human milk on bone mineral content and trace element metabolism*

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We studied the effect of feeding mineral fortifed human milk to preterm infants (birth weight ≤1500 gm). Serum concentrations of calcium, magnesium, phosphorus, zinc, copper, alkaline phosphatase, and parathyroid hormone were determined, and bone mineral content was measured, in infants fed unfortified human milk (group 1), fortified human milk (group 2), and a “humanized,” mineral-enriched premature infant formula (group 3). Serum calcium, magnesium, phosphorus, zinc, copper, and parathyroid hormone concentrations did not differ significantly among the groups studied. Serum alkaline phosphatase concentrations increased significantly only in the infants fed unfortified human milk, and bone mineral content in this group was significantly lower than in formula-fed infants.

References (30)

  • ShawJCL

    Evidence for defective skeletal mineralization in low birth weight infants: the absorption of calcium and fat

    Pediatrics

    (1976)
  • GreerFR et al.

    Calcium and phosphate supplements in breast milk-related rickets: results in a very low birth weight infant

    Am J Dis Child

    (1982)
  • Lewin PK, Reid M, Reilly BJ, Swyer PJ, Fraser D. Iatrogenic rickets in low birth weight infants J Pediatr 78:...
  • AdhamMF et al.

    effect of calcium and copper on zinc absorption in the rat

    Nutr Metab

    (1980)
  • SundermanFW et al.

    Measurements of serum calcium and magnesium by atomic absorption spectrometry

    Am J Clin Pathol

    (1965)
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    *

    Presented in part at the American Society for Bone and Mineral Research, Anaheim, Calif., June 23, 1986.

    Funded by a grant from Mead Johnson Nutritional Group, Evansville, Ind.

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