Abnormalities of diaphragmatic muscle in neonates with ventilated lungs*
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Cited by (81)
Diaphragmatic Thickness and Excursion in Preterm Infants With Bronchopulmonary Dysplasia Compared With Term or Near Term Infants: A Prospective Observational Study
2023, ChestCitation Excerpt :Although no other research on infants with BPD has been published to date, studies have demonstrated the harmful effects of MV on the diaphragm.5,18,26 Knisely et al26 reported that preterm infants who received prolonged MV demonstrated thinning of the diaphragm after the first weeks of age on necropsy samples compared with infants who required only short-term ventilation. Likewise, sonographic studies of children5 and adults18 observed diaphragmatic thinning in patients exposed to MV.
Ultrasound Imaging for Diaphragm Dysfunction: A Narrative Literature Review
2019, Journal of Cardiothoracic and Vascular AnesthesiaCitation Excerpt :Before these 2 studies, only 1 retrospective study of human neonates and 1 study in animals (rats) had provided evidence to support the theory of VIDD. In brief, these landmark studies revealed that 48 hours of controlled MV in humans and animals could lead to a significant loss of diaphragm mass and strength.57,58 The cause seems to stem from the rise in reactive oxygen species in the diaphragm muscle fibers exposed to MV; the dominant site of oxidant production is the mitochondrion, which leads to a rapid decline in protein synthesis.59
Diaphragm Dysfunction in Critical Illness
2018, ChestVentilators and ventilator strategies
2018, Critical Heart Disease in Infants and ChildrenPathophysiology of Ventilator-Dependent Infants
2017, Fetal and Neonatal Physiology, 2-Volume Set
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Presented in part at the 76th annual meeting of the United States and Canadian Academy of Pathology, Chicago, Ill., March 8–13, 1987.