A randomized, placebo-controlled trial of effects of dexamethasone on hypothalamic-pituitary-adrenal axis in preterm infants†
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Cited by (63)
Fetal and Neonatal Endocrinology
2010, Endocrinology: Adult and Pediatric, Sixth EditionImpact of perinatal corticosteroids on neuromotor development and outcome: Review of the literature and new meta-analysis
2009, Seminars in Fetal and Neonatal MedicineCitation Excerpt :In recent years, a number of additional trials have reported long-term follow-up data and one important additional RCT has been reported. In order to enhance this discussion, we have conducted a new meta-analysis of the RCTs that compared dexamethasone with placebo and that have reported long-term follow-up.5,28–32,34–45 These studies were identified by review of previous analyses together with an updated Medline search.
Repeat doses of antenatal steroids and hypothalamic-pituitary-adrenal axis (HPA) function
2007, American Journal of Obstetrics and GynecologyCitation Excerpt :After prolonged postnatal dexamethasone use for chronic lung disease, a transient suppression of HPA axis activity is reported to occur.19-21 Importantly, the adrenal gland is not the only site of suppression, and longer-term effects at the level of the pituitary and hypothalamus37 are still consistent with the reported failure to demonstrate longer-term suppression with the use of ACTH stimulation tests.20,23 Because in the clinical setting false reassurance regarding HPA axis status could lead to delays in supportive treatment for stressed infants, it has been suggested that the ACTH test is insufficient to exclude HPA axis suppression in the neonate.21
Bone metabolism and circulating IGF-I and IGFBPs in dexamethasone-treated preterm infants
1999, Early Human Development
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Supported by research grants HL34118-03 (RLA) and RR00081 from the National Institutes of Health.
Presented in part at the American Thoracic Society, New Orleans, 1987 (Am Rev Respir Dis 1987; 135:A125).