Clinical and laboratory observationNutritional deficits exist before 2 months of age in some infants with cystic fibrosis identified by screening test*
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Cited by (51)
Cystic Fibrosis Diagnosis and Newborn Screening
2016, Pediatric Clinics of North AmericaCitation Excerpt :Most of the disorders on the RUSP are responsive to treatment in the first weeks of life, resulting in a dramatic change in the natural history of the disorder, avoiding significant morbidity and even mortality. Although it is well known that pancreatic disease leading to malabsorption and malnutrition is present at birth,8–13 and lung disease starts early in infancy in CF,14–18 a definitive treatment has not been available that would stop disease progression in CF. Nonetheless, epidemiologic and clinical evidence accumulated throughout the 1980s and 1990s such that the Centers for Disease Control and Prevention (CDC) issued a statement in 2004 that newborn screening for CF is justified based on the benefits of early intervention and nutritional management.19 The strongest evidence of the benefit of early identification through newborn screening that supported the decision by the CDC was in the treatment of early malabsorption and improved growth.20,21
Neonatal Screening and Nutrition/Growth in Cystic Fibrosis: A Review
2015, Diet and Exercise in Cystic FibrosisINTERACTION OF INFECTION AND NUTRITION
2009, Feigin and Cherry's Textbook of Pediatric Infectious Diseases, Sixth EditionAssociation between practice patterns and body mass index percentile in infants and young children with cystic fibrosis
2008, Journal of Cystic FibrosisCitation Excerpt :Increased newborn screening for cystic fibrosis (CF) [1,2] leads to earlier diagnosis of children with CF and prompts clinicians to develop management programs that address nutritional, gastrointestinal, and pulmonary concerns of CF [3,4]. Malnutrition can occur as early as six weeks of age [5], and airway changes (airway wall thickening and dilatation) as early as four months of life [6,7]. Airway infection and inflammation have been recognized in children younger than three years of age [8,9].
Newborn Screening for Cystic Fibrosis
2007, Clinics in Chest MedicineCitation Excerpt :The nutritional benefit of newborn screening has been demonstrated by numerous trials. Investigators in Colorado commonly demonstrated low serum albumin levels and low levels of retinol and α-tocopherol at the initial evaluation of infants diagnosed by newborn screening [11–13]. These low levels of albumin and fat-soluble vitamins are easily corrected by the initiation of pancreatic enzymes and multivitamin therapy.
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Supported in part by grants from the Cystic Fibrosis Foundation, the Bureau of Health Care Delivery and Assistance (SPRANS MCJ-000252), the National Institutes of Health (2 PO HD-04024, HD-00781, and RR-69. General Clinical Research Centers Program of the Division of Research Resources), the American Heart Association, the Colorado Heart Association, and the Grace Jones Richardson Trust.
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Dr. Reardon is a Fellow of the Cystic Fibrosis Foundation. Dr. Bowman is a Clinician Scientist Awardee of the American Heart Association.