Clinical and laboratory observation
Different maturation of neutrophil chemotaxis in term and preterm newborn infants

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    Our results confirm that a neutrophil's ability to perform chemotaxis and phagocytosis is directly correlated with cell maturation and development, suggesting that variations in neutrophil composition at birth may explain previously described functional impairments rather than general global neutrophil dysfunction. Noted improvements in neutrophil function, responsiveness and deformability, as well as increased levels of cell surface adhesion molecules over the first three days of life supports this conclusion as these phenotypic changes are closely associated with normalization of neonatal neutrophil numbers and composition to adult values [1,13,24–26]. Clinical interventions that push neutrophil maturity may, therefore, enhance function and reduce the risk of sepsis.

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