Clinical and laboratory observationPersistence of cytomegalovirus in human milk after storage†
References (10)
- et al.
Prevention of transfusion-acquired cytomegalovirus infections in newborn infants
J Pediatr
(1981) - et al.
Alterations of lymphocytes and of antibody content of human milk after processing
J Pediatr
(1977) - et al.
Breast milk and infant infection
Med J Aust
(1979) - et al.
Cytomegalovirus in human milk
N Engl J Med
(1972) - et al.
Breast milk and the risk of cytomegalovirus infection
N Engl J Med
(1980)
Cited by (66)
High pressure processing inactivates human cytomegalovirus and hepatitis A virus while preserving macronutrients and native lactoferrin in human milk
2022, Innovative Food Science and Emerging TechnologiesCitation Excerpt :While this reduction in infectious CMV independent of processing may have limited our ability to detect larger reductions, we did not observe any statistically significant differences in the concentration of CMV following any of the HPP treatments compared to HoP. Previous studies using cell culture toxicity assays have demonstrated that CMV in human milk is reduced by HoP by greater than 3-log (Dworsky, Stagno, Pass, Cassady, & Alford, 1982; Welsh et al., 1979) and that pressures of >400 MPa (10 min) in cell culture medium result in >4-log PFU/mL reduction in infectious CMV (Nakagami et al., 1992). While this is the first study to our knowledge to quantify infectious CMV in human milk following HPP, we conclude that HPP treatment of greater or equal to 350 MPa, with a minimum hold time of 8 min is sufficient to reduce live CMV by >0.9-log in a human milk matrix.
Cytomegalovirus
2011, Infectious Diseases of the Fetus and Newborn InfantCytomegalovirus
2010, Infectious Diseases of the Fetus and Newborn: Expert Consult - Online and PrintTransmission of cytomegalovirus via breast milk to the prematurely born infant: A systematic review
2010, Clinical Microbiology and InfectionCitation Excerpt :Methods to prevent infection via breast milk in preterm infants include heating and freezing procedures. Holder pasteurization (62.5°C, 30 min) and short–term heating (72°C, 5–10 s) are referred to as the most effective methods for reducing the risk of HCMV transmission via breast milk [11–15]. Although freezing procedures do not completely eliminate the virus, these methods are found to be less harmful to immunological factors contained in breast milk.
- †
Supported by grants from the National Institutes of Child Health and Human Development No. HD 10699, General Clinical Research Center No. 5 M01 RR32, and the National Institutes of Health Fellowship Training Grant No. T32 AI 07041-05.