Elsevier

The Journal of Pediatrics

Volume 101, Issue 3, September 1982, Pages 440-443
The Journal of Pediatrics

Clinical and laboratory observation
Persistence of cytomegalovirus in human milk after storage

https://doi.org/10.1016/S0022-3476(82)80081-4Get rights and content

First page preview

First page preview
Click to open first page preview

References (10)

There are more references available in the full text version of this article.

Cited by (66)

  • High pressure processing inactivates human cytomegalovirus and hepatitis A virus while preserving macronutrients and native lactoferrin in human milk

    2022, Innovative Food Science and Emerging Technologies
    Citation Excerpt :

    While this reduction in infectious CMV independent of processing may have limited our ability to detect larger reductions, we did not observe any statistically significant differences in the concentration of CMV following any of the HPP treatments compared to HoP. Previous studies using cell culture toxicity assays have demonstrated that CMV in human milk is reduced by HoP by greater than 3-log (Dworsky, Stagno, Pass, Cassady, & Alford, 1982; Welsh et al., 1979) and that pressures of >400 MPa (10 min) in cell culture medium result in >4-log PFU/mL reduction in infectious CMV (Nakagami et al., 1992). While this is the first study to our knowledge to quantify infectious CMV in human milk following HPP, we conclude that HPP treatment of greater or equal to 350 MPa, with a minimum hold time of 8 min is sufficient to reduce live CMV by >0.9-log in a human milk matrix.

  • Cytomegalovirus

    2011, Infectious Diseases of the Fetus and Newborn Infant
  • Cytomegalovirus

    2010, Infectious Diseases of the Fetus and Newborn: Expert Consult - Online and Print
  • Transmission of cytomegalovirus via breast milk to the prematurely born infant: A systematic review

    2010, Clinical Microbiology and Infection
    Citation Excerpt :

    Methods to prevent infection via breast milk in preterm infants include heating and freezing procedures. Holder pasteurization (62.5°C, 30 min) and short–term heating (72°C, 5–10 s) are referred to as the most effective methods for reducing the risk of HCMV transmission via breast milk [11–15]. Although freezing procedures do not completely eliminate the virus, these methods are found to be less harmful to immunological factors contained in breast milk.

View all citing articles on Scopus

Supported by grants from the National Institutes of Child Health and Human Development No. HD 10699, General Clinical Research Center No. 5 M01 RR32, and the National Institutes of Health Fellowship Training Grant No. T32 AI 07041-05.

View full text