Elsevier

The Journal of Pediatrics

Volume 90, Issue 1, January 1977, Pages 130-135
The Journal of Pediatrics

Age-related differences in salicylamide and acetaminophen conjugation in man

https://doi.org/10.1016/S0022-3476(77)80787-7Get rights and content

Following a concomitant oral dose of salicylamide and acetaminophen (5 mg/kg of each) the urinary excretion of glucuronide and sulfate conjugates of the drugs were followed in children (ages seven to ten years) and adults. No significant difference was observed between the two age groups in the half-lives for appearance of salicylamide conjugates in urine. Age-related changes in the metabolic pathways, however, were observed. The mean percentage of dose excreted as salicylamide sulfate was significantly higher in children (78%) than in adults (36%). In contrast, salicylamide glucuronide was the major excretory product in adults. Similar age-related differences were observed for acetaminophen conjugation. Pharmacokinetic analysis indicated that the deficiency in glucuronide conjugation of these drugs in children is accompanied by a higher rate of sulfate formation.

References (25)

  • MandelGH et al.

    A study of the metabolism of C14-salicylamide in the human

    J Pharmacol Exp Ther

    (1952)
  • LevyG et al.

    Pharmacokinetics of salicylamide elimination in man

    J Pharmacol Exp Ther

    (1967)
  • Cited by (89)

    • Application of reaction phenotyping to address pharmacokinetic variability in patient populations

      2023, Overcoming Obstacles in Drug Discovery and Development: Surmounting the Insurmountable-Case Studies for Critical Thinking
    • Pharmacokinetics and Pharmacology of Drugs Used in Children

      2019, A Practice of Anesthesia for Infants and Children
    • Pharmacogenomics

      2019, A Practice of Anesthesia for Infants and Children
    • Pharmacogenomics

      2018, A Practice of Anesthesia for Infants and Children
    • Pharmacokinetics and Pharmacology of Drugs Used in Children

      2018, A Practice of Anesthesia for Infants and Children
    • Hepatic Drug Metabolism in Pediatric Patients

      2017, Drug Metabolism in Diseases
    View all citing articles on Scopus

    Supported by United States Public Health Service Grant No. GM 12675 from The National Institutes of Health.

    View full text