Elsevier

The Journal of Pediatrics

Volume 81, Issue 3, September 1972, Pages 532-534
The Journal of Pediatrics

Brief clinical and laboratory observation
Methadone withdrawal in newborn infants

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  • Research gaps on methadone harms and comparative harms: Findings from a review of the evidence for an American Pain Society and College on Problems of drug dependence clinical practice guideline

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    Effects of methadone on neonatal outcomes are difficult to assess because of confounding effects related to selection of the control group (eg, ongoing heroin use or drug-free controls), failure of most studies to adjust for potential confounders, and inconsistent results. Rates of neonatal abstinence syndrome diagnosis in infants of women prescribed methadone were generally 75% or more,28,57,63,64,74,86,96,97,103,104,133 though rates of treatment for neonatal abstinence syndrome were low in some studies.6,39,63,72,109,133 Evidence regarding the comparative incidence, severity, or time course of neonatal abstinence syndrome due to methadone compared to buprenorphine were inconsistent in 4 RCTs and 4 cohort studies, preventing strong conclusions.6,10,46,60,61,63,71,72

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