Elsevier

The Journal of Pediatrics

Volume 61, Issue 3, September 1962, Pages 395-404
The Journal of Pediatrics

The activities of lactate dehydrogenase, transaminase, and glucose-6-phosphate dehydrogenase in the erythrocytes and plasma of newborn infants**

https://doi.org/10.1016/S0022-3476(62)80370-9Get rights and content

The activities of lactate dehydrogenase, glutamic oxalacetic transaminase, and glucose-6-phosphate dehydrogenase in the erythrocytes and plasma of newborn infants have been found to be higher than in adults. The activities of erythrocytic G6PDH and plasma LDH were higher in premature than full-term infants. The high activities of the newborn diminished to adult levels at different rates for each enzyme. The significance of these observations with respect to the assessment of maturity and to the appearance of jaundice in the newborn infant is discussed.

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Cited by (13)

  • The Preterm Infant. A High-Risk Situation for Neonatal Hyperbilirubinemia Due to Glucose-6-Phosphate Dehydrogenase Deficiency

    2016, Clinics in Perinatology
    Citation Excerpt :

    Marks and Gross42 found higher activity in preterm infants than term infants of the same postnatal age, but their analysis pooled infants aged 2 days to 1 year. Stewart and Birkbeck43 did report premature infant G6PD activity higher than in term infants, and term infants were correspondingly higher than adults, while decreasing GA correlated inversely with G6PD activity. Herz and colleagues44 documented higher G6PD activity in low BW infants 865 to 2160 g, but pooled preterm and term neonates.

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**

These studies were supported by grants from the National Research Council of Canada, the Special Services Committee of the University of Alberta Hospital, and the Medical Research Fund of the University of Alberta.

*

Address, Department of Paediatrics, University of Alberta Hospital, Edmonton, Alta.

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