Neonatal interleukin-1β, interleukin-6, and tumor necrosis factor: Cord blood levels and cellular production*
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Nerve cells developmental processes and the dynamic role of cytokine signaling
2019, International Journal of Developmental NeuroscienceCitation Excerpt :Available data from early human studies also suggested that altered cytokine expression in primal life can be associated with the risk of neurodevelopmental disorders (see Young et al., 2016). Concentrations of IL-1β, IL-6 and TNFα were found elevated in infants with severe perinatal complications (Miller et al., 1990) and increased levels of proinflammatory cytokines in amniotic fluid have been proposed as a clinical marker of increased risk for neurological disorders and morbidity (Yoon et al., 1995). As far as specific pathologies are concerned, periventricular leukomalacia was reported to involve cytokine imbalance and microglia activation depleting oIPC and immature neurons in periventricular regions (Deng et al., 2008).
Beyond infection - Maternal immune activation by environmental factors, microglial development, and relevance for autism spectrum disorders
2018, Experimental NeurologyCitation Excerpt :Indeed, altered cytokine expression early in life is increasingly associated with the risk of neurodevelopmental disorders including ASD and severe developmental delay. Concentrations of IL-1β, IL-6, and tumor necrosis factor (TNF) are elevated in infants with severe perinatal complications (Miller et al., 1990), and children with bacterial meningitis have elevated levels of IL-1β that strongly correlate with the occurrence of neurological disorders (Mustafa et al., 1989). Increased levels of IL-6 in amniotic fluid have also been a clinically useful marker of increased risk for neurological disorders and morbidity (Yoon et al., 1995).
Potential biomarkers for effective screening of neonatal sepsis infections: An overview
2017, Microbial PathogenesisCitation Excerpt :Cytokines are unable to pass through placental barrier, and hence, found in umbilical cord blood. Cytokines levels indicate the risk of getting the infection by a neonate in first few hours of life [65,66]. Cytokine levels also predict LOS in the infants [11].
Key Concepts in Immunologic Functions of Human Milk
2017, Fetal and Neonatal Physiology, 2-Volume SetPathophysiology of Neonatal Sepsis
2017, Fetal and Neonatal Physiology, 2-Volume SetPeripheral and central inflammation in autism spectrum disorders
2013, Molecular and Cellular NeuroscienceCitation Excerpt :The increase in the levels of certain, specific brain cytokines and/or chemokines in the maternal blood upon MIA could then reach the fetal brain and affect brain development at different levels. For instance, perinatal complications result in increased concentration of IL-1β, IL-6 and TNF-α in the chord blood (Miller et al., 1990; Yoon et al., 1995). It has been reported that the levels of IL-1β in the cord blood are highly predictive of the neurological outcome of newborns that were exposed to neonatal hypoxia (Aly et al., 2006; Liu and Feng, 2010).
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Supported in part by National Institutes of Health grant No. HD-00850 (Dr. Miller: Association of Medical School Pediatric Department Chairmen, Inc., Pediatric Scientist Training Program Fellow).
Presented in part, in abstract form, at the Second International Workshop on Cytokines, Hilton Head, S.C., Dec. 10–14, 1989.