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Cited by (32)
HEALTH CARE–ASSOCIATED INFECTIONS
2009, Feigin and Cherry's Textbook of Pediatric Infectious Diseases, Sixth EditionTreatment of Dialysis Catheter-Related Staphylococcus aureus Bacteremia With an Antibiotic Lock: A Quality Improvement Report
2007, American Journal of Kidney DiseasesCitation Excerpt :Conversely, a previous study reported a 2-fold greater risk of serious complications with methicillin-resistant S aureus catheter-related bacteremia.15 A number of studies reported a 62% to 100% success rate of an antibiotic lock in salvaging the catheter in patients with bacteremia related to tunneled catheters used for dialysis, chemotherapy, or total parenteral nutrition.5-8,17-21 This approach was endorsed by the Infectious Diseases Society of America for the management of selected patients with catheter-related bacteremia.22
Dialysis catheter-related bacteremia: Treatment and prophylaxis
2004, American Journal of Kidney DiseasesCitation Excerpt :In a randomized study of children with Hickman catheters and catheter-related bacteremia, 63 patients received an antibiotic lock, with or without the addition of intraluminal urokinase. Infection-free survival was similar in both groups (73% versus 70%), suggesting no benefit to urokinase instillation as an adjunct to the antibiotic lock.40 In a second nonrandomized study of children with Broviac catheters and catheter-related bacteremia, infection-free survival was greater for those with systemic antibiotic therapy in conjunction with an ethanol lock compared with systemic antibiotic therapy alone (67% versus 47%).41
Diagnosis and Management of Long-term Central Venous Catheter Infections
2004, Journal of Vascular and Interventional RadiologyInfectious complications of venous access devices
2002, Techniques in Vascular and Interventional RadiologyCitation Excerpt :Although early reports suggest that concurrent thrombolytic and antibiotic therapy may be beneficial in treating catheter-related infection,63 more recent investigations suggest that such therapy is not routinely efficacious. In a study of 63 patients, Atkinson et al demonstrated no benefit to the routine use of urokinase in combination with antibiotic therapy in the absence of documented pericatheter thrombosis or fibrin sheath.64 The authors suggested that thrombolytic therapy be reserved for use in patients with contrast study documentation of pericatheter clot or fibrin sheath.
Decision analysis: A basic overview for the pediatric surgeon
2002, Seminars in Pediatric Surgery