Neonatal apnea, xanthines, and necrotizing enterocolitis*
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Cited by (37)
Evidence-Based Methylxanthine Use in the NICU
2012, Clinics in PerinatologyCitation Excerpt :Death may occur when extreme levels (>40 mg/L) are reached, often through accidental overdose. Reports of an increased risk of necrotizing enterocolitis with methylxanthine use in premature infants have also been observed.19 A subsequent report of 275 infants, however, from Davis and colleagues20 was unable to substantiate any increased clinical risk of theophylline in the development of necrotizing enterocolitis, and a large randomized trial (Caffeine for Apnea of Prematurity Trial) of 2006 infants by Schmidt and colleagues21 similarly failed to show any enhancing effect of caffeine on rates of necrotizing enterocolitis.
Necrotizing enterocolitis and apnoeas-bradycardias of the preterm newborn
2003, Archives de PediatrieMethylxanthine therapy in premature infants: Sound practice, disaster, or fruitless byway?
1999, Journal of PediatricsIndomethacin-induced reduction in neonatal piglet mesenteric blood flow is blunted by dopexamine
1998, Journal of Pediatric SurgeryEnteral hypoxia/ischaemia and necrotizing enterocolitis
1997, Seminars in Neonatology
- *
Presented before the XXIX Annual Congress of the British Association of Paediatric Surgeons, Madrid, Spain, July 21–23, 1982.
- 1
From the Section of Pediatric Surgery, Department of Surgery and the Department of Pathology, Indiana University School of Medicine and the James Whitcomb Riley Hospital for Children, Indianapolis, Ind.