Elsevier

Clinica Chimica Acta

Volume 265, Issue 1, 8 September 1997, Pages 113-119
Clinica Chimica Acta

Research article
Glutathione and neonatal lung disease

https://doi.org/10.1016/S0009-8981(97)00108-3Get rights and content

Abstract

Glutathione (GSH) was measured using HPLC-electrochemical detection in bronchoalveolar lavage fluid from 28 neonates for up to 21 days after birth. GSH levels varied from 0.1–11.2 μmol 1−1 (with a geometric mean concentration of 1.3 μmol l−1). GSH in epithelial lining fluid was estimated using the urea dilution method at 15.0 μmol l−1 (range 0.5–196 μmol l−1), which is significantly lower than observed in adult subjects. There was an L shaped relationship between GSH and the two markers of oxygen therapy, oxygen index and FiO2. The lowest GSH levels were associated with the group of infants with the most severe airways problems who required high oxygen.

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