Perinatal opiate treatment delays growth of cortical dendrites
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2018, Reproductive ToxicologyCitation Excerpt :With increasing gestation, KOR expression on these neurones increased both in fluorescent intensity and varied in the nature of its expression, extending from cytoplasm and cell nucleus to cell processes. This expression on neuronal processes harmonises with functional studies that have linked perinatal opioid exposure with altered axonal growth, dendritic branching, synaptogenesis, neurotransmission and neuronal survival; all changes associated with impaired cognitive and behavioural deficits [46–49]. Buprenorphine has been shown to affect aspects of neuronal maturation and function.
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