SHORT REPORTSLow-dose inhalational nitric oxide in persistent pulmonary hypertension of the newborn
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Inhaled Nitric Oxide in Neonatal Pulmonary Hypertension
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2022, Nitric Oxide - Biology and ChemistryCitation Excerpt :iNO is used for the clinical management of hypoxic respiratory failure in neonates. Several studies have shown that iNO improves oxygenation, reduces pulmonary arterial pressure, and reduces the need for extracorporeal membrane oxygenation (ECMO) in newborns with persistent pulmonary hypertension [217–222]. In 1999, the FDA approved the use of iNO for treating persistent pulmonary hypertension in newborns.
Nitric oxide: Clinical applications in critically ill patients
2022, Nitric Oxide - Biology and ChemistryCitation Excerpt :iNO improves oxygenation and decreases extracorporeal membrane oxygenation (ECMO) use in term and late preterm newborns with PPHN. It was Kinsella et al. [74] and Roberts et al. [75], who first described the benefit of iNO up to 80 ppm on oxygenation in newborns with PPHN. Since then, many trials confirmed these results and found a reduction in ECMO use with iNO treatment [30,38,50,74,75].