Original article: CardiovascularPulmonary vasoconstriction due to impaired nitric oxide production after cardiopulmonary bypass
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2015, Nitric Oxide - Biology and ChemistryCitation Excerpt :Perhaps more frequently, RV dysfunction develops as a manifestation of increased intraoperative PH, and PVR on the background of preoperative right ventricular dysfunction. As many aspects of cardiac surgery including the pulmonary ischemia, the deleterious effects of cardiopulmonary bypass on pulmonary vasoactivity impacts on PVR, endothelial function and NO pathways, treatment of this phenomenon by supplemental delivery of NO seems logical [68,69]. The first series of studies in cardiac surgery have addressed safety, compared efficacy of iNO to other vasodilators, established dose responses and attempted to define conditions when iNO could be especially helpful.
This research was supported by National Heart, Lung, and Blood Institute grants HL-40675 and HL-40922 and by the University of California Tobacco-Related Disease Research program.