Meta-analysis of randomized controlled trials of antenatal corticosteroid for the prevention of respiratory distress syndrome: Discussion,☆☆

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  • Antenatal corticosteroid therapy: Historical and scientific basis to improve preterm birth management

    2019, European Journal of Obstetrics and Gynecology and Reproductive Biology
    Citation Excerpt :

    Monitoring of physical growth in three trials (follow up 3, 6 and up to 12 years old) showed no adverse long-term effects and found no evidence of impaired lung growth. [15]. To meta-analysis by Crowley et al. [13] in the UK with 12 randomized controlled trials and by Crowley [15] in USA with 15 randomized controlled trials, another meta-analysis added by Sinclair [16], with similar results. Therefore, in 1994, NIH sponsored a meeting entitled "Effects of corticosteroids for fetal maturation on perinatal outcomes" in 1994, in order to assess the available data on the prenatal treatment with ACS and develop a consensus, and concluded that corticosteroids reduces respiratory distress syndrome, intraventricular hemorrhage and mortality in preterm infants [5].

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This article is based on the data presented by Dr. Crowley at the Consensus Development Conference on the Effect of Corticosteroids for Fetal Maturation on Perinatal Outcomes, Bethesda, Maryland, February 28–March 2, 1994.

☆☆

A similar report based on this presentation has been previously published: Sinclair JC. Meta-analysis of randomized controlled trials: Antenatal corticosteroid for prevention of respiratory distress syndrome, Prospettive in Pediatria 1994;24:199–206.

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