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Local low-dose urokinase treatment of acquired intracardiac thrombi in preterm infants

  • CARDIOLOGY
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Abstract

We report three cases of intracardiac thrombi in preterm infants of very low birth weight, in whom local low-dose urokinase treatment achieved complete thrombolysis without any signs of systemic fibrinolytic activity or side-effects.

Conclusion This new treatment strategy seems to be safe, requires minimal monitoring of fibrinolytic activity, and may be a new option for thrombolysis in high-risk patients such as premature infants, patients recently operated on, and patients presenting with other contra-indications for systemic fibrinolytic therapy.

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Authors and Affiliations

  1. Critical Care, Cardiology and Hematology-Oncology, Department of Pediatrics, Hôspital des Enfants, University Hospital of Geneva, Rue Willy Donzé 6, CH-1211 Geneva 14, Switzerland, e-mail: Peter.Rimensberger@hcuge.ch, Tel.: 022/382 46 23, Fax: 022/382 46 75, , , , , , CH

    F. Aspesberro, M. Beghetti, I. Oberhänsli, H. Özsahin, J. Humbert & P. C. Rimensberger

Authors
  1. F. Aspesberro
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  2. M. Beghetti
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  3. I. Oberhänsli
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  4. H. Özsahin
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  5. J. Humbert
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  6. P. C. Rimensberger
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Additional information

Received: 4 November 1998 / Accepted in revised form: 5 February 1999

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Aspesberro, F., Beghetti, M., Oberhänsli, I. et al. Local low-dose urokinase treatment of acquired intracardiac thrombi in preterm infants. Eur J Pediatr 158, 698–701 (1999). https://doi.org/10.1007/s004310051182

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  • DOI: https://doi.org/10.1007/s004310051182

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