References
Von Kries R, Hanawa Y (1993) Neonatal Vitamin K Prophylaxis, Thrombosis and Haemostasis 69:293–295
McNinch AW, Tripp JH (1991) Haemorrhagic disease of the newborn in the British Isles: Two years prospective study. Br Med J 303:1105–1108
Cornelissen EAM, Kollée LAA, De Abreu RA, van Baal JM, Motohara K, Verbruggen B and Monnens LAH (1992) Effects of oral and intramuscular vitamin K prophylaxis on vitamin K1, PIVKA-II and clotting factors in breast fed infants. Arch Dis Child 67:1250–1254
Sutor AH, Dagres N, Niederhoff H (1993) Parenteral verabreichtes Vitamin K und erhöhtes Krebsrisiko? Hautnah Paed 3:164–180
Schubiger G, Tönz O, Grüter J, Shearer MJ (1993) Vitamin K1 concentration in breast-fed neonates after oral or intramuscular administration of a single dose of a new mixed micellar preparation of phylloquinone. J Pediatr Gastroenterol Nutr 16:435–439
Øie S, Trenk D, Guentert TW, Mosberg H, Jähnchen E (1988) Disposition of vitamin K1 after intravenous and oral administration to subjects on phenprocoumon therapy. Int J Pharm 48:223–230
McNinch AW, Upton C, Samuels M, Shearer MJ, McCarthy P, Tripp JH, Orme RL (1985) Plasma concentration after oral or intramuscular vitamin K1 in neonates. Arch Dis Child 60:814–818
Amédée-Manesme O, Lambert WE, Alagille D, Leenheer AP (1992) Pharmacokinetics and safety of a new solution of vitamin K1 in children with cholestasis. J Pediatr Gastroenterol Nutr 14:160–165
Widdershoven J, Lambert W, Motohara K, Monnens L, De Leenheer A, Matsuda I, Endo F (1988) Plasma concentrations of vitamin K1 and PIVKA II in bottle-fed and breast-fed infants with and without vitamin K prophylaxis at birth. Eur J Pediatr 148:139–142
Motohara K, Matsukura M, Matsuda I, Iribe K, Ikeda T, Kond Y, Yonekubu A, Yamamoto Y, Tsuchiya Y (1984) Severe vitamin K deficiency in breast-fed infants. J Paediatr 105:943–945
Joubert PH and Stoeckel K (1994) Oral vitamin K in breast-fed infants to prevent late haemorrhagic disease of the new-born. Lancet 344:483–484
McNinch AW and Tripp JH (1991) Haemorrhagic disease of the newborn in the British Isles: two year prospective study. Br Med J 303:1105–1109
Von Kries R, Göbel U (1994) Oral vitamin K prophylaxis and late haemorrhagic disease of the newborn. Lancet 343:352
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Stoeckel, K., Joubert, P.H. & Grüter, J. Elimination half-life of vitamin K1 in neonates is longer than is generally assumed: implications for the prophylaxis of haemorrhaghic disease of the newborn. Eur J Clin Pharmacol 49, 421–423 (1996). https://doi.org/10.1007/BF00203790
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00203790