Abstract
Near infra-red spectroscopy (NIRS) is a non-invasive optical technique used to assess blood and tissue oxygenation and haemodynamics in living tissue. It is presently used as a semi-continuous monitoring technique on a research basis. Multi-regional NIRS information could be beneficial for a better understanding of the development of cerebral injuries and the reduction of neurodevelopmental abnormalities in the human newborn. The paper presents the conversion of the continuous wave NIRS single-channel instrument (NIRDCU) into a prototype four-channel instrument which can be used to provide continuous multi-regional information regarding the cerebral blood oxygenation and haemodynamics in the frontal, left parietal, right parietal and occipital region of the neonatal brain. This has been achieved by attaching an optical multiplexing system to the NIRDCU to select different transmitting and receiving fibres, thus addressing different regions in the brain. Preliminary laboratory tests on a phantom and on the adult forearm are presented, illustrating the practicality of regional monitoring.
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References
Aicardi, J. (1992): ‘Diseases of the nervous system in childhood’ (Mac Keith Press)
Bernert, G., Siebenthal, K., Kohlhauser, C., andCasaer, P. (1995): ‘Near infrared spectroscopy: Methodological principles and clinical application in preterm infants’,Wien Klin Wochenschr.,107, pp. 569–573
Brazy, J. E., Lewis, D. V., Mitnick, M. H., andJobsis, F. F. (1985): ‘Noninvasive monitoring of cerebral oxygenation in preterm infants: preliminary observations’,Paediatrics,75, pp. 217–225
Cope, M., andDelpy, D. T. (1988): ‘System for long-term measurement of cerebral blood and tissue oxygenation on newborn infants by near infra-red transillumination’,Med. Biol. Eng. Comput.,26, pp. 289–294
De Blasi, R. A., Ferrari M., Natali A., Conti G., Mega A., andGasparetto A. (1994): ‘Non-invasive measurement of forearm blood flow and oxygen consumption by near-infrared spectroscopy’,J. Appl. Physiol.,76, pp. 1388–1393
De Blasi, R. A., Ferrari M., Antonelli M., Conti G., Almenrader N., andGasparetto A. (1996): ‘O2 consumption-O2 delivery relationship and arteriolar resistance in the forearm of critically ill patients measured by near infrared spectroscopy’,Shock,6, pp. 319–325
Edwards, A. D., Richardson, C., Cope, M., Wyatt, J. S., Delpy, D. T., andReynolds, E. O. R. (1988): ‘Cotside measurement of cerebral blood flow in ill newborn infants by near infrared spectroscopy,Lancet, pp. 770–771
Faris, F., Rolfe, P., Thorniley, M., Wickramasinghe, Y., Houston, R., Doyle, M., andO'Brien, S. (1992): ‘Non-invasive optical monitoring of cerebral blood oxygenation in the foetus and newborn: preliminary investigation’,J. Biomed. Eng.,14, pp. 303–306
Germon, T. J., Evans, P. E., Barnett, N. J., Lewis, T. T., Wall, P., andNelson, R. J. (1997): ‘Changes in tissue oxyhaemoglobin concentration measured using multi-channel near infrared spectroscopy during internal carotid angiography’,J. Neurol. Neurosurg. Psychiatry.,63, 660–664
Hirth, C., Obrig, H., Villringer, K., Thiel, A., Bernarding, J., Mühlnickel, W., Flor, H., Dirnagl, U., andVillringer, A. (1996): ‘Non-invasive functional mapping of the human motor cortex using near-infrared spectroscopy’,NeuroReport 7, pp. 1977–1981
Hoshi, Y., andTamura, M. (1993): ‘Dynamic multichannel near-infrared optical imaging of human brain activity’,J. Appl. Physiol. 75, pp. 1842–1846
Lehr, H. P., Wickramasinghe, Y., andRolfe, P. (1997): ‘Development of near infra-red spectroscopy for monitoring cerebral regional blood oxygenation and blood volume in the human newborn’,Proc. SPIE,2979, pp. 774–784
McCormick, P. W., Stewart, M., Goetting, M. G., Dujovny, M., Lewis, G., andAusman, J. I. (1991): ‘Noninvasive cerebral optical spectroscopy for monitoring cerebral oxygen delivery and haemodynamics’,Crit. Care Med.,19, 89–97.
Meek, J. H., Tyszczuk, L., Elwell, C. E., andWyatt, J. S. (1998): ‘Cerebral blood flow increases over the first three days in extremely preterm neonates’,Arch. Dis. Child Fetal Neonatal Ed.,78: pp. F33-F37
Moyle, J. T. B., Hahn, C. E. W., andAdams, A. P. (1994): ‘Pulseoximetry’ (BMJ Publishing Group)
Nakagawa, E., Minamitani, H., Ochiai, R., andYamamura, H. (1996): ‘A new system for noninvasive measurement of cerebral regional blood oxygen supply’, Proc. 18th Int. Conf. IEEE Engineering in Medicine and Biology Society, Amsterdam
Nioka, S., Luo, Q., andChance, B. (1997): ‘Human brain functional imaging with reflectance CWS’,Adv. Exp. Med. Biol. 428, pp. 237–242
Pape, K. E., andWigglesworth, J. S. (1979): ‘Haemorrhage, Ischaemia and the Perinatal Brain’, Heinemann, London
Wickramasinghe, Y. A. B. D., Crowe, J. A., andRolfe, P. (1986): ‘Laser source and detector with signal processor for a near infra-red medical application’ in Copeland, K. (Ed.): ‘Progress report on electronics in medicine and biology’ (Institute of Electronics and Radio Engineers, London)
Wickramasinghe, Y. A. B. D., Livera, L. N., Spencer, S. A., Rolfe, P., andThorniley, M. S. (1992): ‘Plethysmographic validation of near infrared spectroscopic monitoring of cerebral blood volume’,Arch. Dis. Child.,76, pp. 407–411
Wickramasinghe, Y. A. B. D., Palmer, K. S., Houston, R., Spencer, S. A., Rolfe, P., Thorniley, M. S., Oeseburg, B., andColier, W. (1993): ‘Effect of fetal hemoglobin on the determination of neonatal cerebral oxygenation by near-infrared spectroscopy’,Pediatr Res,34, 15–17
Wickramasinghe, Y. A. B. D., andRolfe, P. (1993): ‘Modified NIR coefficients taking into account the wavelength dependence of optical pathlength’,Newsletter of EC NIRS & I, No 2, p. 5
Wyatt, J. S., Cope, M., Delpy, D. T., Wray, S., andReynolds, E. O. R. (1986): ‘Quantification of cerebral oxygenation and haemodynamics in sick newborn infants by near infrared spectrophotometry’,Lancet,2, pp. 1063–1066
Wyatt, J. S., Cope, M., Delpy D. T., Richardson, C. E., Edwards, A. D., Wray, S., andReynolds, E. O. R. (1990): ‘Quantitation of cerebral blood volume in human infants by near-infrared spectroscopy,’J. Appl. Physiol.,68, pp. 1086–1091
Wyatt, J. (1997): ‘Cerebral oxygenation and haemodynamics in the foetus and newborn infant’,Phil. Trans. R. Lond. B, pp. 697–700
Yoxall, C. W., andWeindling, A. M. (1997): ‘Measurement of venous oxyhaemoglobin saturation in the adult human forearm by near infrared spectroscopy with venous occlusion’,Med. Biol. Comput. 35, pp. 331–336
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Lehr, H.P., Wickramasinghe, Y. New prototype NIRS to investigate multi-regional cerebral blood and tissue oxygenation and haemodynamics. Med. Biol. Eng. Comput. 38, 281–286 (2000). https://doi.org/10.1007/BF02347048
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DOI: https://doi.org/10.1007/BF02347048