Table 3

Overall outcome indicators, by randomised group

High target (n=130)Control (n=135)p Value
MDI*82 (49–120, 122)84 (49–118, 127)0.79
MDI<8567/122 (55)64/127 (50)0.47
MDI<7037/122 (30)41/127 (32)0.74
PDI*84 (49–114, 109)84 (49–114, 117)0.73
PDI<8556/109 (51)62/117 (53)0.81
PDI<7036/109 (33)39/117 (33)0.96
Total mortality by follow-up27/179 (15)21/180 (12)0.34
Hearing impairment8/127 (6)5/132 (4)0.35
Visual impairment24/127 (19)26/133 (20)0.89
NDI (MDI<70 or PDI<70 or hearing impairment or visual impairment)58/115 (50)57/118 (48)0.75
NDI or death85/142 (60)78/139 (56)0.52
GMFCS level 064 (49)69 (51)0.23
GMFCS level 140 (31)49 (36)
GMFCS level 213 (10)4 (3)
GMFCS level 34 (3)6 (4)
GMFCS level 47 (5)6 (4)
GMFCS level 52 (2)1 (1)
CDI score*22 (1–50, 95)23 (1–58, 88)0.56
Percentiles for CDI scores†5 (<2—>90)10 (<2—>90)
Weight at follow-up (kg)*10.5 (5·6–15.0, 122)10.5 (7.0–17.2, 132)0.84
Height at follow-up (cm)*84 (66–96, 121)85 (70–102, 132)0.40
Head circumference (cm)*47 (40–52, 123)47 (43–50, 130)0.54
Corrected age at follow-up (months)*24 (18–28)24 (19–31)0.46
  • Unless otherwise specified, data are given as number of infants (%), χ2 test.

  • *Median (minimum–maximum, n), Mann-Whitney U-test.

  • †According to the standard sample: median (minimum–maximum).

  • CDI, Child Development Inventory; GMFCS, Gross Motor Function Classification System; MDI, Mental Developmental Index; PDI, Psychomotor Developmental Index.