Univariable and adjusted analyses of perinatal infection/inflammation risk factors and between inflammatory and probable asphyxial factors
| Univariable analysis | Multivariable analysis | |||||
| Risk factor | Case n (%) | Control n (%) | Unadjusted OR | 95% CI | Adjusted OR† | 95% CI |
| Maternal and newborn C reactive protein (CRP) | ||||||
| Maternal CRP | ||||||
| <10th centile (≤4.7 mg/L) | 3/205 (1.5) | 40/407 (9.8) | 1.00 | – | 1.00 | – |
| 10th–90th centile (4.7–86.6 mg/L) | 131/205 (63.9) | 327/407 (80.3) | 5.34 | 1.62 to 17.57 | 5.21 | 1.23 to 22.06 |
| >90th centile (>86.6 mg/L) | 71/205 (34.6) | 40/407 (9.8) | 23.67 | 6.87 to 81.42 | 37.16 | 7.86 to 175.66 |
| Neonatal CRP | ||||||
| <90th centile (<6.6 mg/L) | 159/205 (77.6) | 359/398 (90.2) | 1.00 | – | 1.00 | – |
| 90th–97th centile (6.6–31.7 mg/L) | 29/205 (14.2) | 28/398 (7.0) | 2.34 | 1.35 to 4.06 | 3.17 | 1.57 to 6.41 |
| >97th centile (>31.7 mg/L) | 17/205 (8.3) | 11/398 (2.8) | 3.49 | 1.60 to 7.62 | 9.52 | 3.33 to 27.21 |
| Maternal and newborn infection and inflammation | ||||||
| Neonatal bacteraemia* | 18/210 (8.6) | 2/105 (1.9) | 4.83 | 1.10 to 21.22 | 8.67 | 1.51 to 49.74 |
| Histological chorioamnionitis alone (no funisitis) | 10/60 (16.7) | 11/102 (10.8) | 2.33 | 0.91 to 5.98 | 3.20 | 0.66 to 15.52 |
| Histological funisitis (with chorioamnionitis) | 16/60 (26.7) | 4/102 (3.9) | 10.24 | 3.19 to 32.82 | 11.80 | 2.19 to 63.45 |
*Defined as blood culture and/or species-specific bacterial quantitative Polymerase Chain Reaction (qPCR) for an organism known to be pathogenic among term newborns.
† Adjusted for preconception/antepartum factors in table 2, plus intrapartum factors (augmentation of labour, prolonged labour, obstructed labour and acute intrapartum event).