Published clinical studies about NHFOV in neonates
| Author/year | Sample size | Type of study | Patients' condition | Type of patients | Interface | Generating system | Main results |
|---|---|---|---|---|---|---|---|
| van der Hoeven/199835 | 21 | Case series | RDS, TTN, AOP, air leaks | Term and preterm | Nasopharyngeal tube | Flow-interruption | ↓PaCO2 |
| Hoehn/200036 | 1 | Case report | RDS | Extremely preterm | Nasopharyngeal tube | Flow-interruption | ↓PaCO2 avoid one reintubation |
| Colaizy/200838 | 14 | Non-randomised crossover trial | RDS in recovery phase | Term and preterm | Nasopharyngeal tube | Flow-interruption | NHFOV is safe ↓PaCO2 |
| Czernik/201240 | 20 | Case series | Difficult extubation after various types of respiratory failure | Term and preterm | Nasopharyngeal tube | Piston/membrane | Suggested usefulness for high-risk extubation |
| Aktas/201437 | 3 | Case series | RDS or developing BPD | Extremely preterm | Nasal prongs | Flow-interruption | NHFOV is safe and feasible |
| Mukerji/20146 | 52 | Case series | BPD spells, postextubation, others unspecified | Term and preterm | Nasal prongs/mask | Piston/membrane or flow-interruption | Less spells ↓PaCO2 ↓FiO2 |
| Neonates (total) | 111 | ||||||
Searched in PubMed with NHFOV [All Fields] or non [All Fields] AND invasive [All Fields] AND HFOV [All Fields]. The search was also conducted in Pediatric Academic Societies abstracts archive (2002–2014) and authors’ personal archives (as per 7 February 2016).
Studies are listed in order of publication.
AOP, apnoea of the prematurity; BPD, bronchopulmonary dysplasia; NHFOV, non-invasive high-frequency oscillatory ventilation; RDS, respiratory distress syndrome; TTN, transient tachypnoea of the neonate.