|Author/year||Sample size||Type of study||Patients' condition||Type of patients||Interface||Generating system||Main results|
|van der Hoeven/199835||21||Case series||RDS, TTN, AOP, air leaks||Term and preterm||Nasopharyngeal tube||Flow-interruption||↓PaCO2|
|Hoehn/200036||1||Case report||RDS||Extremely preterm||Nasopharyngeal tube||Flow-interruption||↓PaCO2 avoid one reintubation|
|Colaizy/200838||14||Non-randomised crossover trial||RDS in recovery phase||Term and preterm||Nasopharyngeal tube||Flow-interruption||NHFOV is safe ↓PaCO2|
|Czernik/201240||20||Case series||Difficult extubation after various types of respiratory failure||Term and preterm||Nasopharyngeal tube||Piston/membrane||Suggested usefulness for high-risk extubation|
|Aktas/201437||3||Case series||RDS or developing BPD||Extremely preterm||Nasal prongs||Flow-interruption||NHFOV is safe and feasible|
|Mukerji/20146||52||Case series||BPD spells, postextubation, others unspecified||Term and preterm||Nasal prongs/mask||Piston/membrane or flow-interruption||Less spells|
Searched in PubMed with NHFOV [All Fields] or non [All Fields] AND invasive [All Fields] AND HFOV [All Fields]. The search was also conducted in Pediatric Academic Societies abstracts archive (2002–2014) and authors’ personal archives (as per 7 February 2016).
Studies are listed in order of publication.
AOP, apnoea of the prematurity; BPD, bronchopulmonary dysplasia; NHFOV, non-invasive high-frequency oscillatory ventilation; RDS, respiratory distress syndrome; TTN, transient tachypnoea of the neonate.