|Country||Status (cause)||Patients||Control arm||Primary outcome||Secondary outcomes||Identifier|
|China||Not yet recruiting||>28 weeks; postextubation||NIPPV||Intubation rate||Apnoea, air leaks, BPD, NEC incidence||NCT02543125|
|Canada||Suspended (poor recruitment)||<28 weeks; postextubation||CPAP||Intubation rate||PaCO2, air leaks, IVH, feeding intolerance||NCT01852916|
|Germany||Recruiting||<32 weeks; postextubation||CPAP||PaCO2||Other gas exchange measures, intubation rate, IVH, BPD, NEC||NCT02340299|
|Canada||Recruiting||<1250 g; >72 hours of life; failing postextubation CPAP||BiPAP||Failure of NHFOV/BiPAP||Intubation rate, ventilation length, PaCO2, NICU stay, IVH, BPD, apnoeic spells, common adverse outcomes||NCT02051491|
Search has been conducted using ‘NHFOV’ or ‘HFOV’ and ‘non-invasive’ or ‘NHFIV’ as keywords in ClinicalTrial.gov, IRSCTN Registry and in the Australian-New Zealand Clinical Trials Registry (as per 7 February 2015). All trials have been registered only in ClinicalTrial.gov.
BiPAP, biphasic positive airway pressure; BPD, bronchopulmonary dysplasia; CPAP, continuous positive airway pressure; IVH, intraventricular haemorrhage; NEC, necrotising enterocolitis; NHFOV, non-invasive high-frequency oscillatory ventilation; NICU, neonatal intensive care unit; NIPPV, non-invasive positive pressure ventilation.