Number of registered cases, antenatal detection rate and outcome of pregnancy by anomaly, 1998–2007
| Selected anomalies | ICD code | Total cases | Antenatal detection % (n) | Termination of pregnancy of those antenatally detected % (n) | Outcome of pregnancy for all cases % (n) | |||
|---|---|---|---|---|---|---|---|---|
| Termination of pregnancy | Fetal losses and stillbirth | Live births (surviving >28 days) | Neonatal death | |||||
| Down syndrome (DS) | Q900-9 | 1151 | 57% (657) | 86% (566) | 49% (566) | 6% (65) | 44% (505) | 1% (15) |
| Anencephaly | Q000 | 257 | 97% (249) | 88% (218) | 85% (218) | 8% (20) | 0% (1) | 7% (18) |
| Spina bifida | Q050-Q059 | 339 | 90% (303) | 78% (235) | 70% (235) | 6% (20) | 22% (75) | 2% (8) |
| Hypoplastic left heart | Q234 | 171 | 85% (146) | 56% (82) | 48% (82) | 8% (14) | 25% (42) | 19% (33) |
| Bilateral renal agenesis | Q601/606 | 59 | 81% (48) | 85% (41) | 69% (41) | 15% (9) | 0% (0) | 15% (9) |
| Lethal skeletal dysplasia | Q771-3 | 45 | 82% (37) | 57% (21) | 47% (21) | 7% (3) | 33% (15) | 13% (6) |
| Diaphragmatic hernia | Q790 | 183 | 77% (140) | 29% (40) | 22% (40) | 8% (14) | 47% (86) | 23% (43) |
| Exomphalos | Q792 | 230 | 85% (195) | 56% (109) | 47% (109) | 15% (34) | 34% (77) | 4% (10) |
| Trisomy 18 | Q910-13 | 285 | 85% (242) | 81% (196) | 69% (196) | 13% (38) | 6% (18) | 12% (33) |
| Trisomy 13 | Q914-7 | 127 | 84% (107) | 83% (89) | 70% (89) | 16% (20) | 5% (6) | 9% (12) |
| All FASP9 selected anomalies (excl. DS cases) | 1572 | 86% (1351) | 70% (939) | 60% (939) | 10% (157) | 20% (316) | 10% (160) | |
| All other registered anomalies | 10 857 | – | – | 9% (953) | 4% (486) | 84% (9075) | 3% (343) | |
| Total registered anomalies | 13 580 | – | – | 18% (2458) | 5% (708) | 73% (9896) | 4% (518) | |
FASP, the UK Fetal Anomaly Screening Programme; ICD, International Classification of Diseases.