Time-specific mortality and morbidity to discharge from hospital for all births in England in 2006 between 22 and 26 weeks of gestation
| Outcome | Level 1 services (n=244) | Level 2 services (n=829) | Level 3 services (n=1387) | p Value* | Adjusted OR (95% CI) based on population alive at start of time period | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| Antenatal death | 77 | 32% | 174 | 21% | 208 | 15% | <0.0001 | 0.81 (0.63 to 1.04) | ||
| Delivery room deaths | 43 | 18% | 143 | 17% | 148 | 11% | <0.001 | 0.55 (0.39 to 0.77) | ||
| Neonatal unit deaths <7 days | 38 | 16% | 116 | 14% | 168 | 12% | <0.0001 | 0.65 (0.49 to 0.86) | ||
| All early neonatal deaths | 81 | 33% | 259 | 31% | 316 | 23% | <0.0001 | 0.59 (0.46 to 0.75) | ||
| Late neonatal death (7–28 days) | 12 | 5% | 56 | 7% | 122 | 9% | 0.999 | 0.94 (0.66 to 1.33) | ||
| Death 29 days to discharge | 6 | 2% | 35 | 4% | 86 | 6% | 0.976 | 1.11 (0.72 to 1.72) | ||
| All deaths | 176 | 72% | 524 | 63% | 732 | 53% | <0.0001 | 0.73 (0.59 to 0.90) | ||
| Alive on admission | Live births | Admission to Neonatal unit | ||||||||
| Survivors without morbidity† | 19 | 8% | 70 | 8% | 157 | 11% | 0.017 | 1.27 (0.93 to 1.74) | 1.25 (0.91 to 1.71) | 1.24 (0.90 to 1.71) |
| Survivors only | ||||||||||
| Percent without morbidity† | 28% | 23% | 24% | 0.769 | 1.13 (0.81 to 1.57) | |||||
OR (95% CI) for births in level 3 versus level 2 services adjusted for gestational age and birthweight for gestation.
Heterogeneity of effect of unit level across gestational age found for late neonatal deaths only (p=0.037).
*Significance of χ2 for trend of unadjusted ORs.
†As defined in methods: retinopathy, bronchopulmonary dysplasia, brain injury, necrotising enterocolitis.