Postnatal predictors of retinopathy of prematurity (stages 3–5) in Swedish extremely preterm infants (n=489)
| Period | OR | 95% CI | |
|---|---|---|---|
| Weight ΔSDS | 0–28 days | 0.79 | 0.59 to 1.07 |
| Weight ΔSDS | 8–28 days | 0.78 | 0.59 to 1.03 |
| Weight ΔSDS (GA >23 weeks) | 8–28 days | 0.75* | 0.57 to 0.99 |
| CRIB score (one step increment) | Any | 1.00 | 0.93 to 1.09 |
| Mechanical ventilation† (days) | 0–28 days | 1.19** | 1.08 to 1.33 |
| Postnatal steroids (days) | 0–28 days | 1.19 | 1.00 to 1.41 |
| Antibiotic treatment (days) | 0–28 days | 1.16 | 1.00 to 1.35 |
| Blood transfusion‡ (mL/day) | 0–28 days | 1.23** | 1.09 to 1.39 |
| PDA treatment (any) | Any | 1.95** | 1.26 to 3.02 |
| PDA surgery | Any | 2.28*** | 1.46 to 3.55 |
| IVH any§ (grade 1–4) | Any | 1.57** | 1.04 to 2.36 |
| IVH§ grade 3–4 | Any | 2.13** | 1.12 to 4.03 |
| Enteral fluids¶ (mL/kg/day) | 0–28 days | 0.85*** | 0.78 to 0.93 |
| Hospital | 0.98 | 0.95 to 1.01 |
Logistic regression analysis.
Adjusted for gestational age and birth weight.
*p<0.05; **p<0.01; ***p<0.001.
†One day per week increment.
‡10 mL/kg per week increment.
§One grade increment.
¶Enteral fluids (proportion of total fluids): 10% increment.
ΔSDS, delta SD score; CRIB, clinical risk index for babies; GA, gestational age; IVH, intraventricular haemorrhage; PDA, patent ductus arteriosus.