Table 1

Summary of outcome studies of infants with an Apgar score of 0 at 10 min from the time of the investigational use of therapeutic hypothermia

Study	Year	Gestational age for inclusion (weeks)	Apgar 0 at 10 min n	Age at follow-up (months)	Cooled	Control	Cooled		Control
Study	Year	Gestational age for inclusion (weeks)	Apgar 0 at 10 min n	Age at follow-up (months)	Cooled	Control	Normal	Abnormal	Normal	Abnormal
Laptook	2000–2003	≥36	25	18–22	14	11	4	10	2	9
TOBY	2002–2006	≥36	33	18	16	17	5	11	4	13
ICE	2001–2007	≥35	11	24	5	6	1	4	1	5
Sarkar	2003–2009	≥36	12	9–24	12	0	0	12	0	0
NYPH	2007–2012	≥36	9	18–24	9	0	5	4	0	0
Total			90		56	34	15 (27%)	41 (73%)	7 (21%)	27 (79%)

Abnormal=Death or moderate/severe neurodevelopmental outcome.
ICE, infant cooling evaluation; NYPH, New York-Presbyterian Hospital; TOBY, total body hypothermia for neonatal encephalopathy.