Univariate and multivariate analyses of outcomes for infants 29–31 weeks gestational age
| MgSO4 for fetal neuroprotection (n=656) | No MgSO4 (n=2055) | p Value | Unadjusted OR (95% CI)* | Adjusted OR (95% CI)*† | |
|---|---|---|---|---|---|
| Intensive resuscitation‡, n (%) | 115 (17.5) | 492 (24.2) | <0.01 | 0.67 (0.53 to 0.83) | 0.82 (0.57 to 1.19) |
| Death, n (%) | 6 (0.91) | 42 (2.0) | 0.06 | 0.44 (0.18 to 1.05) | 0.74 (0.36 to 1.51) |
| Bronchopulmonary dysplasia, n (%) | 30 (4.6) | 137 (6.8) | 0.05 | 0.67 (0.44 to 0.99) | 0.73 (0.49 to 1.07) |
| NEC stage ≥2, n (%) | 20 (3.0) | 59 (2.9) | 0.81 | 1.06 (0.63 to 1.78) | 1.03 (0.57 to 1.85) |
| Grade 3 or 4 IVH or PVL, n (%) | 26 (4.5) | 113 (6.6) | 0.07 | 0.67 (0.43 to 1.04) | 0.66 (0.40 to 1.06) |
| ROP stage ≥3, n (%) | 3 (1.3) | 5 (0.8) | 0.56 | 1.53 (0.36 to 6.46) | NA§ |
| Sepsis, n (%) | 50 (7.6) | 140 (6.8) | 0.48 | 1.23 (0.81 to 1.58) | 1.23 (0.91 to 1.67) |
| Composite outcome¶, n (%) | 77 (11.7) | 303 (14.7) | 0.05 | 0.77 (0.59 to 1.01) | 0.77 (0.59 to 1.01) |
*Unadjusted and adjusted OR determined for MgSO4 versus No-MgSO4.
†Adjusted for GA, sex, small for GA, outborn status, chorioamnionitis, mode of delivery, antenatal corticosteroid use and multiple gestation using multiple logistic regression models with GEE approach to account for the correlated data within each site (or site effects).
‡Intensive resuscitation defined as need for intubation and ventilation or chest compressions or epinephrine administration in the delivery room.
§Unable to estimate due to few affected infants.
¶Composite outcome defined as mortality or any major neonatal morbidity.
GA, gestational age; IVH, intraventricular haemorrhage; MgSO4, magnesium sulfate; NEC, necrotising enterocolitis; PVL, periventricular leukomalacia; ROP, retinopathy of prematurity; GEE, generalised estimating equation.