Resuscitation outcomes
| MgSO4 for fetal neuroprotection (n=1387) | No MgSO4 (n=3868) | Difference (95% CI) | p Value* | |
|---|---|---|---|---|
| Any resuscitation needed†, n (%) | 1324 (95.7) | 3624 (93.7) | 2.0 (0.7 to 3.3) | <0.01 |
| CPAP only, n (%) | 561 (40.7) | 1165 (30.5) | 10.2 (7.2 to 13.1) | <0.01 |
| Bag/mask or Neopuff ventilation, n (%) | 781 (56.6) | 2344 (61.4) | −4.8 (−7.8 to −1.7) | <0.01 |
| Intubation and ventilation, n (%) | 557 (40.4) | 1669 (43.7) | −3.3 (−6.4 to −0.3) | 0.03 |
| Chest compressions, n (%) | 54 (3.9) | 266 (6.9) | −3.0 (−4.4 to −1.7) | <0.01 |
| Epinephrine (ETT or IV), n (%) | 26 (1.9) | 119 (3.1) | −1.2 (−2.1 to −0.3) | 0.02 |
| Maximum FiO2, median (IQR) | 60 (40–100) | 80 (40–100) | −20 (−30 to −10) | <0.01 |
| 5 min Apgar <7, n (%) | 412 (29.8) | 1205 (31.6) | −1.8 (−4.7 to 1.0) | 0.20 |
| Surfactant use, n (%) | 735 (53.0) | 2163 (55.9) | −2.9 (−6.0 to 0.1) | 0.06 |
| SNAPII score >20, n (%) | 1086 (79.3) | 3074 (80.6) | −1.3 (−3.8 to 1.2) | 0.28 |
*χ2 test for categorical variables and Wilcoxon Rank Sum test for continuous variables.
†Any resuscitation defined as mask continuous positive airway pressure or positive pressure ventilation, endotracheal tube intubation and ventilation, chest compressions or epinephrine.
CPAP, continuous positive airway pressure; ETT, endotracheal tube; FiO2, fraction of inspired oxygen; IV, intravenous; MgSO4, magnesium sulfate; SNAPII, score for neonatal acute physiology II.