The influence of diagnosis on outcome in infants with TLD
| HIE (n=32) | P/IVH (n=35) | P/IVH+PVL (n=6) | Other ICH (n=5) | ||
|---|---|---|---|---|---|
| Outcome | |||||
| Died in hospital | 22 (68.8%) | 25 (71.4%) | 4 (83.3%) | 4 (80%) | |
| Survived to discharge | 10 (31.2%) | 10 (28.6%) | 1 (16.7%) | 1 (20%) | |
| GOS 1 | 1 (10%) | 3 (30%) | 0 | 0 | |
| GOS 2 | 0 | 3 (30%) | 0 | 1 (100%) | |
| GOS 3 | 0 | 0 | 0 | 0 | |
| GOS 4 | 6 (60%) | 1 (10%)* | ]† | 1 (50%) | 0 |
| Died in infancy/childhood | 3 (30%) | 1 (10%) | 1 (50%) | 0 | |
| N/A | 0 | 2 (20%) | 0 | 0 | |
Neurological outcome and death post-discharge expressed as proportion of infants surviving to discharge.
*p=0.06 (Fisher's exact test, comparing severe disability between infants with HIE and those with P/IVH).
†p<0.01 (Fisher's exact test, comparing combined outcome of death (post-discharge) or severe disability between infants with HIE and those with P/IVH).
GOS, Glasgow Outcome Scale; HIE, hypoxic–ischaemic encephalopathy; P/IVH, periventricular/intraventricular haemorrhage; PVL, periventricular leucomalacia; ICH, intra-cerebral haemorrhage; TLD, treatment limitation discussion.