Characteristics of the patients and major risk factors for invasive fungal infection*
| Variable | Fluconazole (n=93) | Nystatin (n=94) | Control (n=91) | p Value† |
|---|---|---|---|---|
| M/F sex (n) | 48/45 | 50/44 | 48/43 | NS |
| Birth weight (g) | ||||
| Mean | 1127±215 | 1139±211 | 1102±238 | NS |
| Range | 600–1470 | 650–1490 | 600–1490 | |
| Gestational age (week) | ||||
| Mean | 28.6±2.0 | 28.7±2.0 | 28.0±2.3 | NS |
| Range | 24–33 | 25–32 | 24–32 | |
| Vaginal delivery (%) | 26 | 25 | 24 | NS |
| Mean Apgar score at 5 min | 7±1 | 7±2 | 7±2 | NS |
| Mother had pre-eclampsia (%) | 21 | 19 | 19 | NS |
| Rupture of membranes >24 h (%) | 21 | 22 | 24 | NS |
| Antenatal corticosteroids (%) | 84 | 81 | 80 | NS |
| Surfactant (at least once) (%) | 45 | 46 | 46 | NS |
| Third-generation cephalosporins or carbapenems (day) | 5.5±5.7 | 4.9±5.7 | 6.0±5.3 | NS |
| Umblical, central venous and arterial catheter (day) | 3.2±3.7 | 3.7±4.0 | 4.2±4.3 | NS |
| Total parenteral nutrition (day) | 16.3±9.1 | 15.2±8.8 | 17.7±9.5 | NS |
| Vancomycin (%) | 36 | 36 | 38 | NS |
| Systemic corticosteroids (%) | 13 | 16 | 15 | NS |
| Systemic corticosteroids (day) | 2.9±9.1 | 2.7±6.9 | 2.6±7.2 | NS |
| Antibiotic therapy (day) | 18.5±9.4 | 17.5±9.0 | 20.6±9.1 | NS |
| Intubation (%) | 57 | 57 | 59 | NS |
| Intubation (day) | 2.5±4.4 | 2.7±4.2 | 2.6±3.0 | NS |
| Oxygen therapy (day) | 17.6±23.1 | 17.5±22.9 | 20.0±25.0 | NS |
| Caffeine (day) | 21.3±24.6 | 21.5±22.9 | 19.6±22.4 | NS |