Results of screening for subclinical histological chorioamnionitis (HCA) by applying the one minute and five minute perfusion index (PI) cut-off values generated by study phase 1 to an unselected term newborn population recruited prospectively
| Variable | 1 min and 5 min PI < cut-off criteria | |
|---|---|---|
| Yes | No | |
| Where applicable, values are mean (SD). Non-normally distributed continuous variables are expressed as median (25th–75th centiles). Categorical variables are expressed as case numbers with percentages in parentheses. | ||
| Significant pairwise differences, Bonferroni corrected significance levels: *0.05<p<0.01; **0.01<p<0.0001; ***p<0.0001. | ||
| NICU, Neonatal intensive care unit; SGA, small for gestational age; SNAPE-PE, score for neonatal acute physiology-perinatal extension; NTISS, neonatal therapeutic intervention scoring system. | ||
| Number of cases | 32 | 297 |
| M:F | 19:13 | 149:148 |
| Gestational age (weeks) | 39.3 (1.5) | 39.6 (1.0) |
| Birth weight (g) | 3225 (375) | 3380 (440) |
| 1 min perfusion index | 1.53 (0.98) | 3.95 (1.2)*** |
| 5 min perfusion index | 1.98 (1.0) | 4.02 (2.14)*** |
| Confirmative diagnosis of HCA | 30 (93.7%) | 0/297 (0%) |
| 1 min Apgar score | 5 (4–9) | 9 (8–10)* |
| 5 min Apgar score | 9 (7–9) | 9 (9–10) |
| 1 min core temperature (°C) | 37.0 (0.20) | 37.1 (0.15) |
| 1 min skin temperature (°C) | 34.4 (0.34) | 34.7 (0.25) |
| 5 min core temperature (°C) | 37.0 (0.19) | 37.03 (0.31) |
| 5 min skin temperature (°C) | 34.8 (0.31) | 34.8 (0.58) |
| Cord blood pH | 7.303 (0.185) | 7.335 (0.12) |
| Cord blood base excess | −6.1 (4.4) | −1.2 (3.8)*** |
| Admission to NICU | 2 (6.2%) | 14 (4.71%) |
| SGA (birth weight <3rd centile) | 2 (6.2%) | 11 (3.34%) |
| Endotracheal intubation | 1 (3.3%) | 1 (0.9%) |
| SNAP-PE | 3 (3–8) | 0 (0–1)*** |
| NTISS | 2 (1–5) | 0 (0–1)*** |