Table 1

Basic and clinical data on seven breast fed infants with nutritional vitamin B12 deficiency due to maternal vegan diet

	1	2	3	4	5	6	7
MRI, Magnetic resonance imaging; EEG, electroencephalogram.
Sex	Male	Male	Male	Male	Female	Female	Male
Age at onset (months)	5	6	4	6	6	6	9
First symptoms	Failure to thrive, refusal to wean	Failure to thrive, refusal to wean	Focal seizures	Failure to thrive, refusal to wean	Failure to thrive	Failure to thrive	Refusal of solid foods, pallor, weakness
Patient’s history	Vomiting, weight loss, constipation	Irritability, muscular hypotonia, loss of milestone	Seizures	Psychomotor retardation, muscular hypotonia	Severe psychomotor retardation	Vomiting, weight loss	Psychomotor retardation
Mother’ s diet	Vegan	Vegan	Vegan	Vegan	Vegan	Vegan	Diabetic
Diagnostic delay (months)	7	1	–	5	3	2	3
Age at diagnosis (months)	12	7	4	11	9	8	12
Weight/length at diagnosis	<3^rd centile	<3^rd centile	50^th centile	<3^rd centile	<3^rd/10^th centile	<3^rd centile	50^th centile
Presentation at diagnosis	No ability to sit, muscular hypotonia, poor social contact, no vocalisation	Apathy, no ability to sit, muscular hypotonia, poor social contact	Focal seizures	Apathy	Apathy, muscular hypotonia	Apathy	Apathy
MRI at diagnosis	–	–	Mild brain atrophy	Brain atrophy, retarded myelination	Brain atrophy	Brain atrophy	Brain atrophy
EEG at diagnosis	Normal	Normal	Hypsarrhythmia	Moderate diffuse encephalopathy	Normal	–	Normal
Follow up	Improvement of social and motor activity, weight gain	Improvement of social and motor activity, weight gain	Therapy resistant seizures	Improvement of social and motor activity, weight gain	Slow recovery, weight gain	Slow recovery, weight gain	Improvement of social and motor activity, weight gain
MRI follow up	–	–	Brain atrophy	Retarded myelination	Normal	–	Normal
Outcome at age/months	Lost to follow up	Complete recovery /30	West syndrome, mild hemiparesis, no active speech/24	Complete recovery/24	Slight psychomotor retardation, impaired fine motor skills/19	Psychomotor retardation/12	Slight muscular hypotonia/26