Table 4

 Congenital anomaly subgroups by region, number, and prevalence per 10 000 registered births

Congenital anomaly†‡GlasgowNorthernNorth Thames WestWessexOxfordNo. of cases resulting in a termination (%)Total
No.Rate¶No.RateNo.RateNo.RateNo.Rate
AVSD, atrial ventricular septal defect.
*p<0.05; **p<0.01; ***p<0.001.
†Includes live births, stillbirths, fetal deaths from 20 weeks gestation, and terminations of pregnancy.
‡Some cases had more than one anomaly.
§‘Non-chromosomal’ includes the anomalies cited plus anophthalmos, microphthalmos, absence of auricle/ear, microtia, chondrodystrophy, osteodystrophies,
¶Per 10 000 registered births.
††Including five cases of submucous cleft palate.
‡‡Excluding 30 non-postcoded cleft palate cases, some of which would have resided in the study wards.
Non-chromosomal (total)§865109.1308499.6187469.598272.533373.11811 (25.4)7138***
Nervous system18122.863920.649918.526019.28017.61177 (70.9)1659
Neural tube defects13617.248415.633212.317112.65411.9957 (81.3)1177***
Anencephalus and similar556.92207.11535.7856.3275.9483 (89.4)540
Spina bifida637.92207.11415.2715.2255.5384 (73.8)520**
Hydrocephaly364.51264.11214.5705.2255.5177 (46.8)378
Congenital heart disease27534.7122639.642915.928320.911224.6254 (10.9)2323***
Anomalies of cardiac chambers577.22006.51224.5805.9184.053 (11.1)477**
Transposition of great vessels455.71223.9762.8433.2143.118 (6.0)300**
Malformations of cardiac septa13216.740012.91425.3654.8235.178 (10.3)760***
AVSD40.5551.8291.1251.810.228 (24.8)113**
Tetralogy of Fallot313.9963.1261.0201.592.012 (6.6)181***
Malformations of valves8711.056518.31646.1705.25913.0144 (15.2)945***
Hypoplastic left heart141.8722.3652.4372.771.583 (42.6)195
Malformation of great arteries and veins13316.82909.41455.41118.25011.053 (7.3)728***
Coarctation of aorta212.61013.3341.3332.4153.310 (4.9)204***
Cleft lip with/without palate779.72207.12378.81088.0367.956 (8.3)678
Cleft palate55††6.91274.11264.742‡‡3.1122.621 (5.8)361***
Digestive system739.22056.61686.2856.3132.965 (17.8)544**
Tracheo-oesophageal fistula, oesophageal atresia and stenosis253.2872.8521.9332.430.713 (6.5)200*
Small intestine atresia111.4501.6301.1322.451.16 (4.7)128*
Ano-rectal atresia and stenosis374.7682.2863.2201.551.146 (21.3)216***
Internal urogenital system: ovaries, uterus, renal13116.537912.264223.832023.6388.3460 (30.5)1,507***
Bilateral renal agenesis151.9371.2331.2191.440.973 (67.6)108
Cystic kidney disease384.81565.01525.6644.7214.6102 (23.8)429
Limb reduction defects607.61274.11043.9463.4194.259 (16.6)355***
Miscellaneous8310.52949.51947.2946.9235.1188 (27.3)688***
Diaphragmatic hernia334.21023.3642.4322.471.569 (29.0)238*
Omphalocele232.9692.2782.9292.181.893 (44.9)207
Gastroschisis253.21294.2542.0312.381.832 (13.0)247***
Multiples13316.833210.71646.115811.7367.9308 (37.4)823***
Chromosomal22928.9117037.8104538.757942.717839.11415 (44.2)3201***
Down’s syndrome14318.052216.958421.628120.710923.9716 (43.7)1,639***
Trisomy 13 (Patau)91.1511.6532.0261.9143.1100 (65.4)153
Trisomy 18 (Edwards)293.71143.71355.0685.0255.5244 (65.8)371
Other chromosomal anomalies506.349315.927310.120315.0306.6358 (34.1)1,049***
New dominant162.0481.6341.3181.361.349 (40.2)122
Syndromes354.41033.31495.5856.3112.496 (25.1)383***
Total no. of registered births and termination of pregnancy79258309460269796135469455383226/10844 (31.2)839521