Clinical and biochemical data according to outcome
| Group 1 (n = 17) | Group 2 (n = 8) | Group 3 (n = 11) | Group 4 (n = 7) | |
|---|---|---|---|---|
| Clinical data are expressed as mean (range). Initial (within 24 hours of birth) antioxidant concentration and mean malondialdehyde concentration are expressed as mean (SEM). | ||||
| *Significantly (p < 0.05) different from group 1. | ||||
| †Significantly (p < 0.05) different from group 3. | ||||
| Group 1, Babies who survived without O2 requirement; group 2, O2 dependent at 28 days postnatal age but not at 36 weeks post-conceptional age; group 3, O2 dependent at 36 weeks post-conceptional age (BPD); group 4, babies who died. | ||||
| Gestational age (weeks) | 29 (26–31) | 27 (26–28)* | 26 (24–29)* | 25 (24–28)* |
| Birth weight (g) | 1306 (845–2300) | 920 (754–1200)* | 773 (535–1476)* | 635 (464–834)* |
| Peak Fio2 in first 24 hours | 44 (21–97) | 42 (22–69) | 43 (21–66) | 62 (32–100) |
| Peak inspiratory pressure in first 24 hours | 18 (14–30) | 17 (12–20) | 18 (14–24) | 21 (18–26) |
| First estimated A/a ratio | 0.31 (0.13–0.51) | 0.28 (0.19–0.35) | 0.40 (0.18–0.76) | 0.18 (0.1–0.27)† |
| No of blood transfusions received | 0.3 (0–2) | 1.9 (1–5) | 8.8 (0–16)* | 5.4 (0–13)* |
| Total volume of blood received (ml) | 6.9 (0–24) | 28.0 (15–67)* | 135.4 (0–271)* | 58.4 (0–115)* |
| No of BAL samples taken | 1.7 (1–4) | 3.3 (1–5) | 4.9 (2–9) | 4.0 (1–7) |
| Return of BAL fluid (%) | 36.6 (21.7–65.5) | 43.9 (24.0–60.6) | 56.0 (28.5–74.0) | 73.4 (63.0–99.0) |
| Glutathione concentration (μM) | ||||
| ELF | 10.76 (2.97) | 4.19 (2.16) | 1.89 (0.62)* | 2.96 (0.96) |
| BAL | 0.653 (0.231) | 0.174 (0.077) | 0.093 (0.039) | 0.115 (0.038) |
| Plasma | 0.693 (0.168) | 0.294 (0.115) | 0.192 (0.063)* | 0.267 (0.073) |
| Ascorbate concentration (μM) | ||||
| ELF | 27.57 (9.04) | 31.72 (12.01 | 30.34 (12.48) | 15.24 (4.28) |
| BAL | 1.32 (0.26) | 1.10 (0.46) | 1.54 (0.51) | 0.94 (0.36) |
| Plasma | 71.05 (13.35) | 59.83 (15.79) | 60.54 (11.50) | 69.42 (23.93) |
| Urate concentration (μM) | ||||
| ELF | 261.91 (40.68) | 495.21 (98.13) | 331.65 (49.29) | 215.25 (37.25) |
| BAL | 17.33 (2.11) | 19.53 (3.07) | 14.20 (2.61) | 10.35 (1.73) |
| Plasma | 540.46 (44.12) | 534.35 (98.54) | 381.59 (47.52)* | 439.23 (65.26) |
| Malondialdehyde concentration | ||||
| ELF (μM) | 0.345 (0.095) (n = 16) | 1.150 (0.577) (n = 3) | 1.300 (0.313) (n = 10)* | 0.912 (0.364) (n = 6) |
| BAL (nM) | 18.43 (5.02) (n = 16) | 18.18 (1.57) (n = 3) | 52.76 (13.22) (n = 10)* | 36.01 (13.87) (n = 6) |