Timing of injury to the central nervous system after cerebral insult
| Pathological feature | Timing of onset after injury | References |
|---|---|---|
| Neuronal eosinophilia | 6–24 hours | 60–62 |
| Neuronal karyorrhexis | 12–48 hours | 61, 63–65 |
| Infarcts—necrosis | 3–8 hours | 60, 65, 66 |
| Infarcts—cavitation | 14–42 days | 65–68 |
| White matter gliosis | 3–11 days | 31, 32, 58, 60, 61, 65, 67, 69, 70 |
| Grey matter gliosis | 3–5 days | 30, 63, 68, 71 |
| Microglial upregulation | 3 hours–3 days | 60, 61, 66, 67, 71 |
| Macrophage infiltration | 3–7 days | 63, 65–68 |
| Fresh haemorrhage | Minutes | 67 |
| Haemosiderin deposits | 2–3 days | 27, 67, 72 |
| Mineralisation | 3–14 days | 58, 60, 65, 67 |