Classification of fetal and neonatal thrombocytopenias
| Condition | |
|---|---|
| The most common conditions are highlighted. | |
| CMV, Cytomegalovirus; ITP, idiopathic thrombocytopenic purpura; SLE, systemic lupus erythematosus; PET, pre-eclampsia; IUGR, intrauterine growth restriction; E coliEscherichia coli; GBS, group B streptococcus; DIC, disseminated intravascular coagulation; TAR, thrombocytopenia with absent radii; CAMT, congenital amegakaryocytic thrombocytopenia; NEC, necrotising enterocolitis. | |
| Fetal | Alloimmune |
| Congenital infection (e.g. CMV, toxoplasma, rubella, HIV) | |
| Aneuploidy (e.g. trisomies 18, 13, 21, or triploidy) | |
| Autoimmune (e.g. ITP, SLE) | |
| Severe Rh haemolytic disease | |
| Congenital/inherited (e.g. Wiskott-Aldrich syndrome) | |
| Early onset neonatal (<72 hours) | Placental insufficiency (e.g. PET, IUGR, diabetes) |
| Perinatal asphyxia | |
| Perinatal infection (e.g. E coli, GBS, Haemophilus influenzae) | |
| DIC | |
| Alloimmune | |
| Autoimmune (e.g. ITP, SLE) | |
| Congenital infection (e.g. CMV, toxoplasma, rubella, HIV) | |
| Thrombosis (e.g. aortic, renal vein) | |
| Bone marrow replacement (e.g. congenital leukaemia) | |
| Kasabach-Merritt syndrome | |
| Metabolic disease (e.g. proprionic and methylmalonic acidaemia) | |
| Congenital/inherited (e.g. TAR, CAMT) | |
|
Late onset neonatal (>72 hours) | Late onset sepsis |
| NEC | |
| Congenital infection (e.g. CMV, toxoplasma, rubella, HIV) | |
| Autoimmune | |
| Kasabach-Merritt syndrome | |
| Metabolic disease (e.g. proprionic and methylmalonic acidaemia) | |
| Congenital/nherited (e.g. TAR, CAMT) | |