Changes in concentrations of serum and urinary bone markers in very low birthweight infants in the corticosteroid and the non-treatment groups
| Corticosteroid group (n=19) | Non-treatment group (n=30) | |||||||
|---|---|---|---|---|---|---|---|---|
| Before treatment (Td-pre) | End of treatment (Td-end) | 2 weeks after end of treatment (Td-post 2) | 4 weeks after end of treatment (Td-post 4) | Week 3 (Twk-3) | Week 6 (Twk-6) | Week 8 (Twk-8) | Week 10 (Twk-10) | |
| Results are median (interquartile range). | ||||||||
| BALP, bone specific alkaline phosphatase; Dpd, deoxypyridinoline. | ||||||||
| BALP (U/l) | 307 (212–389) | 177 (126–268) | 266 (195–367) | 312 (192–340) | 220 (117–307) | 309 (204–380) | 329 (254–411) | 341 (292–518) |
| Osteocalcin (ng/l) | 15.8 (11.1–21.0) | 7.7 (4.9–13.6) | 12.8 (9.6–19.3) | 14.7 (10.5–17.2) | 12.9 (7.6–16.5) | 17.2 (10.3–24.7) | 16.6 (9.8–25.3) | 18.1 (11.2–28.4) |
| Dpd (nmol/mmol Cr) | 27.1 (20.9–45.3) | 23.4 (17.0–32.6) | 44.7 (25.8–56.6) | 45.0 (31.1–62.0) | 26.2 (13.1–35.7) | 31.8 (21.8–40.3) | 31.5 (25.8–41.1) | 40.6 (30.7–50.5) |