Table 1

Normal nucleated red blood cell (nRBC) count

Reference (first author) Sample size nRBCs Age Gestation/birth weight
Naeye10 84919 (1425) nRBCs/mm3 1 hourTerm, AGA
560 (771) nRBCs/ mm3 6 hours
Green11 102400 (1300) nRBCs/mm3 12–24 hours37–41 weeks, AGA
Sinha12 842.3 (0.7) nRBCs/100 WBCsBirth (cord blood)2501 and 3500 g
Shivhare13 334.1 (2.4) nRBCs/100 WBCsBirth (cord blood)Term and near-term
Phelan14 833.4 (3.0) nRBCs/100 WBCsBirth (cord blood)⩾37 weeks, >2700 g
Hanlon-Lundberg15 1,1128.5 (10.3) nRBCs/100 WBCsBirth (cord blood)37–41 weeks1-150
Green16 262900 (3600) nRBCs/mm3 Day 123–26 weeks
371200 (1800) nRBCs/mm3 Day 127–29 weeks
861000 (900) nRBCs/mm3 Day 130–32 weeks
Buonocore17 478521 (1620) nRBCs/mm3 Birth (cord blood)24–27 weeks
1854548 (473) nRBCs/mm3 Birth (cord blood)28–36 weeks
1051689 (290) nRBCs/mm3 Birth (cord blood)37–41 weeks
Axt18 3043.7 (median) nRBCs/100 WBCsBirth (cord blood)261–289 days
6.5 (median)nRBCs/100 WBCsBirth (cord blood)290+ days
  • Results are mean (1 SD).

  • 1-150 Excludes eight infants with extreme idiopathic increases (>100 nRBCs/100 WBCs) and includes infants with maternal diabetes, growth retardation, birth asphyxia, and other causes known to increase the circulating nRBCs.

  • AGA, appropriate size for gestational age; WBC, white blood cell.