Patient no | Total volume of blood transfused (ml) | Net volume of blood transfused (ml) | Serum iron (μmol/l) | TIBC (μmol/l) | % Saturation | Serum ferritin (pmol/l) | Liver iron concentration (μmol/g (mg/g) dry weight) | Liver histology | Cause of death and relevant clinical details | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Grade (0–4) | Kupffer cells | Hepatocytes | |||||||||||||||||
Group A (n=9): infants receiving <100 ml of blood | |||||||||||||||||||
1 | 8 | 2.6 | 12 | 28 | 43 | 299 | 8.3 (0.5) | 0 | − | − | RDS | ||||||||
2 | 11 | 5.1 | 6 | 15 | 40 | 126 | 6.3 (0.4) | 0 | − | − | RDS | ||||||||
3 | 32 | 13.7 | 16 | 23 | 70 | 902 | 15.4 (0.9) | 0 | − | − | RDS, air embolism | ||||||||
4 | 35 | 29.3 | 13 | 38 | 34 | 352 | 8.8 (0.5) | 0 | − | − | RDS | ||||||||
5 | 20 | 15.0 | 13 | 29 | 45 | 297 | 8.6 (0.5) | 0 | − | − | RDS | ||||||||
6 | 51 | 27.9 | 16 | 14 | 114 | 2 330 | 30.5 (1.7) | 2 | ++ | − | RDS, Aplasia cutis congenita | ||||||||
7 | 62 | 37.4 | 14 | 16 | 88 | 678 | 16.4 (0.9) | 1 | + | − | RDS | ||||||||
8 | 60 | 46.8 | 6 | 6 | 100 | 488 | 24.5 (1.4) | 1 | + | − | Severe intraventricular haemorrhage | ||||||||
9 | 67 | 26.4 | 12 | 12 | 100 | 10 772 | 17.1 (1.0) | 1 | + | − | RDS | ||||||||
Group B (n=8): infants receiving ⩾100 ml of blood | |||||||||||||||||||
10 | 370 | 234.8 | 24 | 42 | 57 | 2 809 | 64.3 (3.6) | 2 | ++ | − | BPD, cholestatic jaundice | ||||||||
11 | 171 | 107.9 | 17 | 26 | 65 | 4 840 | 17.1 (1.0) | 1 | + | − | RDS | ||||||||
12 | 180 | 98.1 | 26 | 42 | 62 | 44 880 | 28.2 (1.6) | 1 | + | − | NEC, cholestatic jaundice | ||||||||
13 | 133 | 43.0 | 19 | 22 | 86 | 2 200 | 14.2 (0.8) | 0 | − | − | Severe intraventricular haemorrhage | ||||||||
14 | 213 | 93.5 | 11 | 21 | 52 | 11 726 | 43.2 (2.4) | 1 | + | − | NEC, septicaemia | ||||||||
152-150 | 480 | 293.2 | 22 | 22 | 100 | 20 790 | 69.4 (3.9) | 3 | +++ | + | BPD, cholestatic jaundice | ||||||||
162-150 | 1034 | 616.0 | 48 | 51 | 94 | 9 306 | 99.8 (5.6) | 3 | +++ | + | BPD | ||||||||
17 | 188 | 35.0 | 25 | 32 | 78 | 3 036 | 168.3 (9.4) | 2 | ++ | + | Pulmonary hypoplasia, ? Larsen's syndrome |
↵2-150 Double volume exchange transfusion.
TIBC, total iron binding capacity; RDS, respiratory distress syndrome; BPD, bronchopulmonary dysplasia; NEC, necrotising enterocolitis.