Table 2

Results for primary outcome measures in preterm infants receiving either oral vitamin A supplementation or placebo

Vitamin A (n=77) Placebo (n=77) RR (95% CI) p Value
Survived52 (68%)48 (62%)1.12 (0.81 to 1.61)0.50
CLD at 28 days in survivors43 (83%)42 (88%)0.84 (0.57 to 1.46)0.86
Survived without CLD at 28 days9 (12%)6 (8%)1.23 (0.71 to 1.75)0.41
CLD at 36 weeks in survivors40 (77%)37 (77%)1.0 (0.67 to 1.64)0.98
Survived without CLD at 36 weeks12 (16%)11 (14%)1.05 (0.65 to 1.52)0.82
Median (IQR) time ventilated (days)14 (4–24)15 (7–33)0.21
Pulmonary haemorrhage5 (6%)11 (14%)0.60 (0.27 to 1.10)0.13
Pneumothorax11 (14%)17 (22%)0.75 (0.44 to 1.15)0.24
Treatment for retinopathy6 (8%)6 (8%)1.0 (0.50 to 1.58)0.98
Survived without significant retinopathy45 (57%)45 (53%)1.02 (0.74 to 1.44)0.92
PDA17 (22%)16 (21%)1.12 (0.74 to 1.59)0.84
NEC9 (12%)7 (9%)1.14 (0.66 to 1.66)0.58
Survived without significant IVH48 (62%)41 (54%)1.19 (0.86 to 1.68)0.29
Median (IQR) number of sepsis episodes1 (0–2)1 (0–2)0.89
Vomiting1 (1%)5 (6%)0.32 (0.06 to 1.11)0.10
Seizures15 (19%)20 (26%)0.82 (0.52 to 1.20)0.38
  • CLD, chronic lung disease; IQR, interquartile range; PDA, patent ductus arteriosus; NEC, necrotising enterocolitis; IVH, intraventricular haemorrhage.