Difference between osmolality values (mean and 95 % confidence interval) of human milk after supplementation with different HMF at various concentrations observed at T2 (24 hours after reconstitution), T1 ( 10 minutes after), and T0 (theoretical osmolality)
| N = | T1-T0 | T2-T1 | T1-T0 vs T2- T1 | |
|---|---|---|---|---|
| HMF1 | 6 | 0.33; (−4.1 to 4.8); p<0.86 | 7.2; (3.7 to 10.6), p<0.005 | P = 0.02 |
| HMF2(2.5%) | 10 | 13.2; (23 to 70) , p<0.001 | 21.5; (13.6 to 29.3), p< 0.001 | P = 0.01 |
| HMF2(5%) | 7 | 23.4; (17.5 to 29.3), p<0.001 | 42; (29.7 to 54.3), p<0.001 | P = 0.003 |
| HMF3(2.5%) | 4 | 17.5; (−1.3to 36.3), p = 0.06 | 28.3; (21.7 to 34.8), p<0.001 | P = 0.25 NS |
| HMF3(5%) | 6 | 31.5; (22.9 to 40.1), p<0.001 | 63.8; (52.6 to 75.0), p<0.001 | P = 0.002 |
| HMF4(4%) | 7 | 24; (21.6 to 26.4), p<0.001 | 6.9; (4.8 to 9), p<0.001 | P<0.0001 |
| HMF5(4%) | 7 | 26.7; (23.2 to 30.2), p<0.001 | 18.1; (14.7 to 21.5), p<0.001 | P<0.001 |
Osmolality values are expressed in mosmol/kg H2O.