Maternal data
| Mother no | Type of epilepsy | Epileptic attack during pregnancy | Medication | Daily dose of antiepileptic drug(s) in g/24 hours + range of plasma concentrations of (total valproate) and [free valproate] in μmol/l | Poor compliance | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1st trimester | 2nd trimester | 3rd trimester | |||||||||
| 1 | Primary generalised | Valproate | 1.0 | 1.0→1.5 (238–348) [29–63] | 1.5 (226–338) [28–54] | ||||||
| 2 | Primary generalised | Valproate | 0.9 (310–343) | 0.9 | 0.9→2.1 (212–362) | ||||||
| 3 | Primary generalised | Valproate | 0.6 | 0.6 (243) | 0.6→2.1 (250–583) | ||||||
| 4 | Primary generalised | Valproate | 0.6 | 0.6→0.9 (247) | 0.9 (298–427) | ||||||
| 5 | Primary generalised | Valproate | 1.0 (412) [27] | 1.0 (306–381) [26–39] | 1.0 (262–304) [29–35] | ||||||
| 6 | Complex partial | + | Valproate | 1.1 | 1.1 | 1.1→1.5 (280–319) | |||||
| 7 | Primary generalised | Valproate | 1.0 | 1.0 (275–422) [38–63] | 1.3 (274–408) [42–55] | ||||||
| 8 | Primary generalised | Valproate | 1.0 (122) [7] | 1.0 (266–267) [27] | 1.0 (146–204) [17–26] | ||||||
| 9 | Primary generalised | Valproate | 0.5 (329) [32] | 0.5 (239–275) [21–25] | 0.5 (222–247) [23–24] | ||||||
| 10 | Primary generalised | Valproate | 1.0 (273–290) [24–28] | 1.0 (264–290) [23–38] | 1.0 (174–392) [21–53] | ||||||
| 11 | Primary generalised | Valproate | 1.0 (607) [50] | 1.0 (390–536) [49–56] | 1.0 (251–304) [31–56] | ||||||
| 12 | Primary generalised | Valproate | 0.9 (327) | 0.9 (238–309) | 1.2→1.5 (334–362) | ||||||
| 13 | Primary generalised | Valproate | 0.8 (269) [18] | 0.8→1.0 (281–321) [19–25] | 1.0 (272–360) [35–42] | ||||||
| 14 | Primary generalised | Valproate | 1.6 (434) [43] | 1.6 (373–615) [65–70] | 1.6 (308–422) [30–52] | ||||||
| 15 | Primary generalised | Valproate | 1.5 (283) [20] | 1.5 (249–314) [24–38] | 1.5 (269–312) [29–33] | ||||||
| 16 | Primary generalised | Valproate | 1.2 (416) [55] | 1.2→1.5 (287–310) [20–47] | 1.5 (278–314) [30–51] | ||||||
| 17 | Primary generalised | Valproate | 1.0 (302) [20] | 1.0 (223–260) [20–27] | 1.0 (179–225) [19–33] | ||||||
| 18 | Primary generalised | Valproate | 0.3 (78) [3] | 0.3 (77–82) [5] | 0.3 (52–63) [5] | ||||||
| 19 | Primary generalised | Valproate | 0.9 (264–373) [22–40] | 0.9 (236–334) [34–58] | 0.9 (195–260) [31–45] | ||||||
| 20 | Primary generalised | Valproate | 1.0 (568–609) [62] | 1.0 (469–537) [56–64] | 1.0 (422–436) [51–69] | ||||||
| 21 | Complex partial | + | Valproate | 4.2 | 4.8 (22–446) [6–81] | 4.8 (238–316) [44–78] | + | ||||
| carbamazepine | 2.4 | 2.8 (6–44) [2–10] | 2.8 (23–29) [7–16] | ||||||||
| 22 | Complex partial | + | Valproate | 1.5 (289) [26] | 1.5 (108–165) [15–26] | 1.5 (123–141) [12] | |||||
| carbamazepine | 1.0 (26) [7] | 1.0 (25) [5] | 1.0 (22–29) [5–11] | ||||||||